Cocaine and cocaethylene binding to human tissues: A preliminary study

被引：10

作者：

Bailey, DN

机构：

[1] Division of Laboratory Medicine, Department of Pathology, University of California, San Diego

[2] Department of Pathology, UCSD Medical Center, San Diego, CA 92103-8320

来源：

THERAPEUTIC DRUG MONITORING | 1996年 / 18卷 / 03期

关键词：

binding; cocaethylene; cocaine; equilibrium dialysis; human tissues;

D O I：

10.1097/00007691-199606000-00010

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 [基础医学];

摘要：

The tissue binding of cocaine (COG) and cocaethylene (CE) was investigated by equilibrium dialysis of homogenates of whole human tissue supplemented with either COC or CE at concentrations of 10 and 50 mu M for each drug. Concentrations of COC and CE were measured by high-pressure liquid chromatography. Kidney bound COC predominantly whereas serum bound it the least (about one tenth as much). In contrast, for CE, most binding was noted to brain with the least to serum (about one twentieth as much). Heart, placenta, and liver showed intermediate binding overall. The binding of COC and CE to these tissues may be important in understanding specific target-organ activity of both compounds.

引用

页码：280 / 283

页数：4

共 18 条

[1]

CHARACTERIZATION OF A COCAINE BINDING-PROTEIN IN HUMAN PLACENTA [J].