Alzheimer's disease and brain reserve

被引：17

作者：

Schofield, P ^{[1
]}

机构：

[1] Hunter Area Mental Hlth, Neuropsychiat Serv, Newcastle, NSW 2300, Australia

来源：

AUSTRALASIAN JOURNAL ON AGEING | 1999年 / 18卷 / 01期

关键词：

D O I：

10.1111/j.1741-6612.1999.tb00081.x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Alzheimer's disease has a long early phase in which limited pathological changes accumulate without apparent functional consequences. Once pathology exceeds a certain threshold, clinical features arise, but this threshold seems to differ from patient to patient, reflecting individual differences in 'brain reserve'. This review discusses the concept and possible determinants of brain reserve, and their implications for the diagnosis of Alzheimer's disease.

引用

页码：10 / 14

页数：5

共 45 条

[41] PHYSICAL BASIS OF COGNITIVE ALTERATIONS IN ALZHEIMERS-DISEASE - SYNAPSE LOSS IS THE MAJOR CORRELATE OF COGNITIVE IMPAIRMENT [J].

TERRY, RD ;

MASLIAH, E ;

SALMON, DP ;

BUTTERS, N ;

DETERESA, R ;

HILL, R ;

HANSEN, LA ;

KATZMAN, R .

ANNALS OF NEUROLOGY, 1991, 30 (04) :572-580

[42] OBSERVATIONS ON BRAINS OF DEMENTED OLD PEOPLE [J].

TOMLINSON, BE ;

BLESSED, G ;

ROTH, M .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1970, 11 (03) :205-+

[43] OBSERVATIONS ON BRAINS OF NON-DEMENTED OLD PEOPLE [J].

TOMLINSON, BE ;

BLESSED, G ;

ROTH, M .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1968, 7 (02) :331-+

[44]

WHO, 1992, The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines

[45] INVIVO BRAIN SIZE AND INTELLIGENCE [J].

WILLERMAN, L ;

SCHULTZ, R ;

RUTLEDGE, JN ;

BIGLER, ED .

INTELLIGENCE, 1991, 15 (02) :223-228

← 1 2 3 4 5 →