Substituted 1,3,5-Triazaadamantanes: Biocompatible and Degradable Building Blocks

被引：22

作者：

Balija, Amy M. ^{[1
]}

Kohman, Richie E. ^{[1
]}

Zimmerman, Steven C. ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 42期

基金：

美国国家卫生研究院;

关键词：

degradation; dendrimers; host-guest systems; hydrolysis; macromolecules;

D O I：

10.1002/anie.200802222

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Basic groups from acid hydrolysis: 1,3,5-Triazaadamantanes (TAAs) are shown to degrade in acidic conditions to produce basic byproducts (see scheme). The rate of hydrolysis can be tuned by changing the substituents present on the aromatic rings. TAA-containing dendrimers can be synthesized readily as a result of the branched architecture ofthe TAA building blocks. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8072 / 8074

页数：3

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