A review on chitosan and its development as pulmonary particulate anti-infective and anti-cancer drug carriers

被引：102

作者：

Rasul, Ruhisy Mohd ^{[1
,2
]}

Muniandy, M. Tamilarasi ^{[1
,3
]}

Zakaria, Zabliza ^{[1
,4
]}

Shah, Kifayatullah ^{[5
]}

Chee, Chin Fei ^{[6
]}

Dabbagh, Ali ^{[7
]}

Abd Rahman, Noorsaadah ^{[3
]}

Wong, Tin Wuiy ^{[1
,4
,8
]}

机构：

[1] Univ Teknol MARA Selangor, Nondestruct Biomed & Pharmaceut Res Ctr, iPROMISE, Puncak Alam 42300, Selangor, Malaysia

[2] Univ Teknol MARA, Fac Sci Appl, Shah Alam 40450, Selangor, Malaysia

[3] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur 50603, Malaysia

[4] Univ Teknol MARA Selangor, Particle Design Res Grp, Fac Pharm, Puncak Alam, Selangor, Malaysia

[5] Gomal Univ, Dept Pharmaceut, Fac Pharm, Dera Ismail Khan, Khyber Pakhtunk, Pakistan

[6] Univ Malaya, Nanotechnol & Catalysis Res Ctr, Kuala Lumpur 50603, Malaysia

[7] Taylors Univ, Sch Med, Fac Hlth & Med Sci, Subang Jaya, Malaysia

[8] Yangzhou Univ, Sino Malaysia Mol Oncol & Tradit Chinese Med Deli, Yangzhou, Jiangsu, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2020年 / 250卷

关键词：

Cancer; Chitosan; Infection; Nanoparticle; Pulmonary drug delivery; N-SUBSTITUTED CHITOSAN; IN-VITRO EVALUATION; DELIVERY-SYSTEMS; LUNG-CANCER; ANTIBACTERIAL ACTIVITY; TARGETED DELIVERY; SURFACE CHARACTERISTICS; CARBOXYMETHYL CHITOSAN; ANTIMICROBIAL ACTIVITY; INHALATION TREATMENT;

D O I：

10.1016/j.carbpol.2020.116800

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Chitosan, as a biodegradable and biocompatible polymer, is characterized by anti-microbial and anti-cancer properties. It lately has received a widespread interest for use as the pulmonary particulate backbone materials of drug carrier for the treatment of infectious disease and cancer. The success of chitosan as pulmonary particulate drug carrier is a critical interplay of their mucoadhesive, permeation enhancement and site/cell-specific attributes. In the case of nanocarriers, various microencapsulation and micro-nano blending systems have been devised to equip them with an appropriate aerodynamic character to enable efficient pulmonary aerosolization and inhalation. The late COVID-19 infection is met with acute respiratory distress syndrome and cancer. Chitosan and its derivatives are found useful in combating HCoV and cancer as a function of their molecular weight, substituent type and its degree of substitution. The interest in chitosan is expected to rise in the next decade from the perspectives of drug delivery in combination with its therapeutic performance.

引用

页数：17

共 190 条

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Inhalable particulate drug delivery systems for lung cancer therapy: Nanoparticles, microparticles, nanocomposites and nanoaggregates [J].