Biochemistry - An enzyme assembly line

被引:39
作者
Smith, Janet L. [1 ,2 ]
Sherman, David H. [1 ,3 ,4 ,5 ]
机构
[1] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Med Chem, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
[5] Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA
关键词
D O I
10.1126/science.1163785
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:1304 / 1305
页数:2
相关论文
共 12 条
[1]   Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula [J].
Chang, ZX ;
Sitachitta, N ;
Rossi, JV ;
Roberts, MA ;
Flatt, PM ;
Jia, JY ;
Sherman, DH ;
Gerwick, WH .
JOURNAL OF NATURAL PRODUCTS, 2004, 67 (08) :1356-1367
[2]   The evolution of gene collectives: How natural selection drives chemical innovation [J].
Fischbach, Michael A. ;
Walsh, Christopher T. ;
Clardy, Jon .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (12) :4601-4608
[3]   Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids [J].
Gokhale, Rajesh S. ;
Saxena, Priti ;
Chopra, Tarun ;
Mohanty, Debasisa .
NATURAL PRODUCT REPORTS, 2007, 24 (02) :267-277
[4]   GNAT-like strategy for polyketide chain initiation [J].
Gu, Liangcai ;
Geders, Todd W. ;
Wang, Bo ;
Gerwick, William H. ;
Hakansson, Kristina ;
Smith, Janet L. ;
Sherman, David H. .
SCIENCE, 2007, 318 (5852) :970-974
[5]   Architecture of a fungal fatty acid synthase at 5 Å resolution [J].
Jenni, S ;
Leibundgut, M ;
Maier, T ;
Ban, N .
SCIENCE, 2006, 311 (5765) :1263-1267
[6]   The structure of a ketoreductase determines the organization of the β-carbon processing enzymes of modular polyketide synthases [J].
Keatinge-Clay, AT ;
Stroud, RM .
STRUCTURE, 2006, 14 (04) :737-748
[7]   Architecture of mammalian fatty acid synthase at 4.5 Å resolution [J].
Maier, T ;
Jenni, S ;
Ban, N .
SCIENCE, 2006, 311 (5765) :1258-1262
[8]   The crystal structure of a mammalian fatty acid synthase [J].
Maier, Timm ;
Leibundgut, Marc ;
Ban, Nenad .
SCIENCE, 2008, 321 (5894) :1315-1322
[9]   Escherichia coli induces DNA double-strand breaks in eukaryotic cells [J].
Nougayrede, Jean-Philippe ;
Homburg, Stefan ;
Taieb, Frederic ;
Boury, Michele ;
Brzuszkiewicz, Elzbieta ;
Gottschalk, Gerhard ;
Buchrieser, Carmen ;
Hacker, Joerg ;
Dobrindt, Ulrich ;
Oswald, Eric .
SCIENCE, 2006, 313 (5788) :848-851
[10]   The 2.7-Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase [J].
Tang, Yinyan ;
Kim, Chu-Young ;
Mathews, Irimpan I. ;
Cane, David E. ;
Khosla, Chaitan .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (30) :11124-11129