Lipid imaging with cluster time-of-flight secondary ion mass spectrometry

被引：71

作者：

Brunelle, Alain ^{[1
]}

Laprevote, Olivier ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, Lab Spectrometrie Masse, UPR 2301, F-91198 Gif Sur Yvette, France

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2009年 / 393卷 / 01期

关键词：

Mass spectrometry imaging; Lipids; Cluster ion source; TOF-SIMS; RAT-BRAIN TISSUE; DYSTROPHIC MUSCLE; SECTIONS; SIMS;

D O I：

10.1007/s00216-008-2367-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This brief article provides an overview of the current state of the art in biological imaging mass spectrometry using cluster time-of-flight secondary ion mass spectrometry (TOF-SIMS). Recent and spectacular improvements in terms of sensitivity of TOF-SIMS imaging methods have allowed many biological applications to recently be successfully tested, such as mapping of lipid disorders in human muscles of a patient suffering from dystrophy, localization of surfactins after the swarming of bacteria on a surface, or lipid mapping over whole-body animal sections.

引用

页码：31 / 35

页数：5

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