The high-affinity IgG receptor, FcγRI, plays a central role in antibody therapy of experimental melanoma

被引：90

作者：

Bevaart, L

Jansen, MJH

van Vugt, MJ

Verbeek, JS

van de Winkel, JGJ

Leusen, JHW

机构：

[1] Univ Utrecht, Ctr Med, Dept Immunol, Immunotherapy Lab, NL-3584 EA Utrecht, Netherlands

[2] Genmab, Utrecht, Netherlands

[3] Leiden Univ, Ctr Med, Ctr Human & Clin Genet, Leiden, Netherlands

来源：

CANCER RESEARCH | 2006年 / 66卷 / 03期

关键词：

D O I：

10.1158/0008-5472.CAN-05-2856

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

We examined the role of Fc gamma R in antibody therapy of metastatic melanoma in wild-type and different Fc gamma R knockout mice. Treatment of B16F10-challenged wild-type mice with TA99 antibody specific for the gp75 tumor antigen resulted in a marked decrease in numbers of lung metastases. Treatment of individual Fc gamma R knock-out mice revealed the high-affinity IgG receptor, Fc gamma RI (CD64), to represent the central Fc gamma R for TA99-induced antitumor effects. The potential of immunemodulating agents to further enhance the protective effect induced by monoclonal antibody (mAb) TA99 was examined in combination treatments consisting of mAb TA99 and a TLR-4 agonist, monophosphoryl lipid A (MPL). MPL did potently boost TA99 antibody-induced effects, and combination therapy was, again, found to be dependent on the presence of Fc gamma RI.

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页码：1261 / 1264

页数：4

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