Black phosphorus-based 2D materials for bone therapy

被引：104

作者：

Cheng, Liang ^{[1
]}

Cai, Zhengwei ^{[1
,2
]}

Zhao, Jingwen ^{[1
]}

Wang, Fei ^{[1
]}

Lu, Min ^{[1
]}

Deng, Lianfu ^{[1
]}

Cui, Wenguo ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed,Sch Med, Shanghai Key Lab Prevent & Treatment Bone & Joint, Shanghai 200025, Peoples R China

[2] Jiaxing Univ, Dept Orthopaed, Jiaxing Key Lab Basic Res & Clin Translat Orthope, Affiliated Hosp 2, 1518 North Huancheng Rd, Jiaxing 314000, Peoples R China

来源：

BIOACTIVE MATERIALS | 2020年 / 5卷 / 04期

基金：

国家重点研发计划;

关键词：

Tissue engineering; Nanomaterial; Black phosphorus; Bone therapy; PROMOTE OSTEOBLASTIC DIFFERENTIATION; STEM-CELL; DELIVERY-SYSTEMS; MATRIX VESICLES; DEFECT REPAIR; OSTEOGENIC DIFFERENTIATION; HIERARCHICAL STRUCTURE; HOLLOW MICROSPHERES; WHITE PHOSPHORUS; ORAL DELIVERY;

D O I：

10.1016/j.bioactmat.2020.06.007

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Since their discovery, Black Phosphorus (BP)-based nanomaterials have received extensive attentions in the fields of electromechanics, optics and biomedicine, due to their remarkable properties and excellent biocompatibility. The most essential feature of BP is that it is composed of a single phosphorus element, which has a high degree of homology with the inorganic components of natural bone, therefore it has a full advantage in the treatment of bone defects. This review will first introduce the source, physicochemical properties, and degradation products of BP, then introduce the remodeling process of bone, and comprehensively summarize the progress of BP-based materials for bone therapy in the form of hydrogels, polymer membranes, microspheres, and three-dimensional (3D) printed scaffolds. Finally, we discuss the challenges and prospects of BP-based implant materials in bone immune regulation and outlook the future clinical application.

引用

页码：1026 / 1043

页数：18

共 245 条

[1]

High-Performance p-BP/n-PdSe2 Near-Infrared Photodiodes with a Fast and Gate-Tunable Photoresponse [J].