Biomarkers in the assessment and management of airways diseases

被引：23

作者：

Taylor, D. R. ^{[1
]}

Pavord, I. D. ^{[2
]}

机构：

[1] Univ Otago, Dunedin Sch Med, Dunedin, New Zealand

[2] Glenfield Gen Hosp, Univ Hospitals Leicester Trust, Dept Resp Med, Leicester LE3 9QP, Leics, England

来源：

POSTGRADUATE MEDICAL JOURNAL | 2008年 / 84卷 / 998期

关键词：

D O I：

10.1136/pgmj.2008.069864

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A plethora of biomarkers are becoming available in the field of respiratory medicine, but their application in clinical practice has been limited. This is changing. There is increasing scope for biomarkers to be used to define pathological as well as treatment responder phenotypes in asthma and chronic obstructive pulmonary disease. In some situations, conventional diagnostic labelling is being superseded by this approach and clinical outcomes are improved. Biomarkers are potentially very important in the development and assessment of new therapeutic agents, particularly for the treatment of severe asthma. They also have a potential role in monitoring disease activity and predicting future clinical outcomes for asthma and chronic obstructive pulmonary disease. Current evidence in relation to these issues is explored in this review.

引用

收藏

页码：628 / 634

页数：7

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