mRNA on the Move: The Road to Its Biological Destiny

被引：56

作者：

Eliscovich, Carolina ^{[1
]}

Buxbaum, Adina R. ^{[1
]}

Katz, Zachary B. ^{[1
]}

Singer, Robert H. ^{[1
,2
]}

机构：

[1] Yeshiva Univ, Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

[2] Yeshiva Univ, Albert Einstein Coll Med, Gruss Lipper Biophoton Ctr, Bronx, NY 10461 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2013年 / 288卷 / 28期

基金：

美国国家卫生研究院;

关键词：

ZIPCODE-BINDING-PROTEIN; DROSOPHILA HNRNPA/B HOMOLOG; GROWTH CONE GUIDANCE; BETA-ACTIN SYNTHESIS; IN-VIVO; LIVING CELLS; NUCLEOCYTOPLASMIC TRANSPORT; INTRACELLULAR-LOCALIZATION; CYTOPLASMIC LOCALIZATION; DEPENDENT LOCALIZATION;

D O I：

10.1074/jbc.R113.452094

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Cells have evolved to regulate the asymmetric distribution of specific mRNA targets to institute spatial and temporal control over gene expression. Over the last few decades, evidence has mounted as to the importance of localization elements in the mRNA sequence and their respective RNA-binding proteins. Live imaging methodologies have shown mechanistic details of this phenomenon. In this minireview, we focus on the advanced biochemical and cell imaging techniques used to tweeze out the finer aspects of mechanisms of mRNA movement.

引用

页码：20361 / 20368

页数：8

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