Gas chromatographic mass spectrometric determination of lysergic acid diethylamide (LSD) in serum samples

被引：20

作者：

Musshoff, F ^{[1
]}

Daldrup, T ^{[1
]}

机构：

[1] UNIV DUSSELDORF,INST LEGAL MED,D-40225 DUSSELDORF,GERMANY

来源：

FORENSIC SCIENCE INTERNATIONAL | 1997年 / 88卷 / 02期

关键词：

lysergic acid diethylamide (LSD); gas chromatography mass spectrometry; analytical backdrops;

D O I：

10.1016/S0379-0738(97)00063-7

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

A sensitive method for the detection and quantification of lysergic acid diethylamide (LSD) in serum samples is described. After liquid-liquid extraction the trimethylsilyl derivative of LSD is detected by gas chromatography - mass spectrometry. Experiments with spiked samples resulted in a recovery of 76%, the coefficient of variation was 9.3%. Excellent linearity was obtained over the range 0.1-10 ng ml(-1). Additionally experiments demonstrating the light sensitivity of LSD are presented together with casuistics. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：133 / 140

页数：8

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