Chitosan Electrodeposition for Microrobotic Drug Delivery

被引：93

作者：

Fusco, Stefano ^{[1
]}

Chatzipirpiridis, George ^{[1
]}

Sivaraman, Kartik M. ^{[1
]}

Ergeneman, Olgac ^{[1
]}

Nelson, Bradley J. ^{[1
]}

Pane, Salvador ^{[1
]}

机构：

[1] ETH, Inst Robot & Intelligent Syst, CH-8092 Zurich, Switzerland

来源：

ADVANCED HEALTHCARE MATERIALS | 2013年 / 2卷 / 07期

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

chitosan; electrodeposition; drug delivery; microrobotics; smart materials; CONTROLLED-RELEASE; POLYELECTROLYTE COMPLEXATION; ANTICANCER DRUG; GEL BEADS; HYDROGELS; NANOPARTICLES; ENHANCEMENT; VEHICLE; DESIGN; SYSTEM;

D O I：

10.1002/adhm.201200409

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A method to functionalize steerable magnetic microdevices through the co-electrodeposition of drug loaded chitosan hydrogels is presented. The characteristics of the polymer matrix have been investigated in terms of fabrication, morphology, drug release and response to different environmental conditions. Modifications of the matrix behavior could be achieved by simple chemical post processing. The system is able to load and deliver 40-80 g cm(-2) of a model drug (Brilliant Green) in a sustained manner with different profiles. Chitosan allows a pH responsive behavior with faster and more efficient release under slightly acidic conditions as can be present in tumor or inflamed tissue. A prototype of a microrobot functionalized with the hydrogel is presented and proposed for the treatment of posterior eye diseases.

引用

页码：1037 / 1044

页数：8

共 53 条

[21] OctoMag: An Electromagnetic System for 5-DOF Wireless Micromanipulation [J].

Kummer, Michael P. ;

Abbott, Jake J. ;

Kratochvil, Bradley E. ;

Borer, Ruedi ;

Sengul, Ali ;

Nelson, Bradley J. .

IEEE TRANSACTIONS ON ROBOTICS, 2010, 26 (06) :1006-1017

[22] Effect of genipin-crosslinked chitin-chitosan scaffolds with hydroxyapatite modifications on the cultivation of bovine knee chondrocytes [J].

Kuo, Yung-Chih ;

Lin, Chih-Yu .

BIOTECHNOLOGY AND BIOENGINEERING, 2006, 95 (01) :132-144

[23]

Kuppermann B. D, 2006, RET EM NEW CONC HELD

[24] Small-scale systems for in vivo drug delivery [J].

LaVan, DA ;

McGuire, T ;

Langer, R .

NATURE BIOTECHNOLOGY, 2003, 21 (10) :1184-1191

[25] Electrodeposition of chitosan-hemoglobin films [J].

Li, Y. ;

Pang, X. ;

Epand, R. F. ;

Zhitomirsky, I. .

MATERIALS LETTERS, 2011, 65 (10) :1463-1465

[26] A glucose biosensor based on chitosan-glucose oxidase-gold nanoparticles biocomposite formed by one-step electrodeposition [J].

Luo, XL ;

Xu, JJ ;

Du, Y ;

Chen, HY .

ANALYTICAL BIOCHEMISTRY, 2004, 334 (02) :284-289

[27] Modified chitosan 4. Superabsorbent hydrogels from poly(acrylic acid-co-acrylamide) grafted chitosan with salt- and pH-responsiveness properties [J].

Mahdavinia, GR ;

Pourjavadi, A ;

Hosseinzadeh, H ;

Zohuriaan, MJ .

EUROPEAN POLYMER JOURNAL, 2004, 40 (07) :1399-1407

[28] Chitosan-Coated Wires: Conferring Electrical Properties to Chitosan Fibers [J].

Meyer, W. Lee ;

Liu, Yi ;

Shi, Xiao-Wen ;

Yang, Xiaohua ;

Bentley, William E. ;

Payne, Gregory F. .

BIOMACROMOLECULES, 2009, 10 (04) :858-864

[29]

Mi FL, 1999, J APPL POLYM SCI, V74, P1868, DOI 10.1002/(SICI)1097-4628(19991114)74:7<1868::AID-APP32>3.0.CO

[30]

2-N

← 1 2 3 4 5 6 →