Host Defense and Pathogenesis in Staphylococcus aureus Infections

被引：179

作者：

DeLeo, Frank R. ^{[1
]}

Diep, Binh An ^{[2
]}

Otto, Michael ^{[1
]}

机构：

[1] NIAID, NIH, Lab Human Bacterial Pathogenesis, Rocky Mt Labs, Hamilton, MT 59840 USA

[2] Univ Calif San Francisco, Dept Med, Div Infect Dis, San Francisco, CA 94110 USA

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2009年 / 23卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Staphylococcus; Neutrophil; Innate immunity; Virulence; PANTON-VALENTINE LEUKOCIDIN; HUMAN POLYMORPHONUCLEAR LEUKOCYTES; COMMUNITY-ASSOCIATED MRSA; CATABOLIC MOBILE ELEMENT; PEPTIDE-SENSING SYSTEM; SOFT-TISSUE INFECTIONS; TOXIC-SHOCK-SYNDROME; METHICILLIN-RESISTANT; HUMAN-NEUTROPHILS; IMMUNE EVASION;

D O I：

10.1016/j.idc.2008.10.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Staphylococcus aureus is the most abundant cause of bacterial infections in the United States. As such, the pathogen has devised means to circumvent destruction by the innate immune system. Neutrophils are a critical component of innate immunity and the primary cellular defense against S aureus infections. This article reviews human neutrophil function in the context of S aureus virulence mechanisms and provides an overview of community-associated methicillin-resistant S aureus pathogenicity.

引用

页码：17 / +

页数：19

共 100 条

[31] Epidemiologic distribution of the arginine catabolic mobile element among selected methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates [J].

Goering, Richard V. ;

McDougal, Linda K. ;

Fosheim, Greg E. ;

Bonnstetter, Kristin K. ;

Wolter, Daniel J. ;

Tenover, Fred C. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (06) :1981-1984

[32] Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1 [J].

Gómez, MI ;

Lee, A ;

Reddy, B ;

Muir, A ;

Soong, G ;

Pitt, A ;

Cheung, A ;

Prince, A .

NATURE MEDICINE, 2004, 10 (08) :842-848

[33] Survival of Staphylococcus aureus inside neutrophils contributes to infection [J].

Gresham, HD ;

Lowrance, JH ;

Caver, TE ;

Wilson, BS ;

Cheung, AL ;

Lindberg, FP .

JOURNAL OF IMMUNOLOGY, 2000, 164 (07) :3713-3722

[34] Toll-like receptors stimulate human neutrophil function [J].

Hayashi, F ;

Means, TK ;

Luster, AD .

BLOOD, 2003, 102 (07) :2660-2669

[35] Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk [J].

Herold, BC ;

Immergluck, LC ;

Maranan, MC ;

Lauderdale, DS ;

Gaskin, RE ;

Boyle-Vavra, S ;

Leitch, CD ;

Daum, RS .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (08) :593-598

[36] DEGRANULATION OF POLYMORPHONUCLEAR LEUCOCYTES FOLLOWING PHAGOCYTOSIS OF MICROORGANISMS [J].

HIRSCH, JG ;

COHN, ZA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1960, 112 (06) :1005-&

[37] Complete genomes of two clinical Staphylococcus aureus strains:: Evidence for the rapid evolution of virulence and drug resistance [J].

Holden, MTG ;

Feil, EJ ;

Lindsay, JA ;

Peacock, SJ ;

Day, NPJ ;

Enright, MC ;

Foster, TJ ;

Moore, CE ;

Hurst, L ;

Atkin, R ;

Barron, A ;

Bason, N ;

Bentley, SD ;

Chillingworth, C ;

Chillingworth, T ;

Churcher, C ;

Clark, L ;

Corton, C ;

Cronin, A ;

Doggett, J ;

Dowd, L ;

Feltwell, T ;

Hance, Z ;

Harris, B ;

Hauser, H ;

Holroyd, S ;

Jagels, K ;

James, KD ;

Lennard, N ;

Line, A ;

Mayes, R ;

Moule, S ;

Mungall, K ;

Ormond, D ;

Quail, MA ;

Rabbinowitsch, E ;

Rutherford, K ;

Sanders, M ;

Sharp, S ;

Simmonds, M ;

Stevens, K ;

Whitehead, S ;

Barrell, BG ;

Spratt, BG ;

Parkhill, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (26) :9786-9791

[38]

Hunt C, 1999, JAMA-J AM MED ASSOC, V282, P1123

[39] Staphylococcal complement evasion by various convertase-blocking molecules [J].

Jongerius, Ilse ;

Kohl, Jorg ;

Pandey, Manoj K. ;

Ruyken, Maartje ;

van Kessel, Kok P. M. ;

van Strijp, Jos A. G. ;

Rooijakkers, Suzan H. M. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (10) :2461-2471

[40] Distinction between pore assembly by staphylococcal α-toxin versus leukotoxins [J].

Joubert, Olivier ;

Voegelin, Joelle ;

Guillet, Valerie ;

Tranier, Samuel ;

Werner, Sandra ;

Colin, Didier A. ;

Serra, Mauro Dalla ;

Keller, Daniel ;

Monteil, Henri ;

Mourey, Lionel ;

Prevost, Gilles .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2007,

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