Diastereoselective alkylation of 8-phenylmenthyl 2-methylacetoacetate. Preparation of enantiomerically pure 4,4-disubstituted 2-pyrazolin-5-ones

被引：6

作者：

MorenoManas, M ^{[1
]}

Sebastian, RM ^{[1
]}

Vallribera, A ^{[1
]}

Molins, E ^{[1
]}

Espinosa, E ^{[1
]}

机构：

[1] CSIC,INST CIENCIA MAT BARCELONA,E-08193 CERDANYOLA,SPAIN

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(97)00131-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Alkylation of (1R,3R,4S)-8-phenylmenthyl 2-methylacetoacetate with alkyl halides affords 2-alkyl-2-methylacetoacetates in diastereomeric ratios 72:28 to 85:15. The major R (at C-alpha) diastereoisomers are converted into enantiopure 4,4-disubstituted 2-pyrazolin-5-ones with recovery of the chiral inductor. (C) 1997 Elsevier Science Ltd.

引用

页码：1525 / 1527

页数：3

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