Highly enantioselective organocatalytic formation of a quaternary carbon center via chiral Bronsted acid catalyzed self-coupling of enamides

被引：89

作者：

Baudequin, Christine ^{[1
]}

Zamfir, Alexandru ^{[1
]}

Tsogoeva, Svetlana B. ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Chem & Pharm, Chair Organ Chem 1, D-91054 Erlangen, Germany

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 38期

关键词：

D O I：

10.1039/b804477e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective BINOL-phosphate catalyzed formation of a quaternary carbon center, bearing a N-atom has been achieved through the self-coupling reaction of enamides; the corresponding products have been isolated in up to > 99% ee and their application for the synthesis of versatile synthetic building blocks-beta-aminoketones-has been demonstrated.

引用

页码：4637 / 4639

页数：3

共 64 条

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