Design and synthesis of sialyl Le(X) mimetics based on carbocyclic scaffolds' derived from (-) quinic acid

被引：24

作者：

Hanessian, S ^{[1
]}

Reddy, GV ^{[1
]}

Huynh, HK ^{[1
]}

Pan, JW ^{[1
]}

Pedatella, S ^{[1
]}

Ernst, B ^{[1
]}

Kolb, HC ^{[1
]}

机构：

[1] NOVARTIS PHARMA LTD,BASEL,SWITZERLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(97)10077-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of sialyl Lewis(x) mimetic anologs in which the D-glucosamine, D-galactose, and sialic acid residues are replaced individually with appropriate glycomimetics is described. A computational model for predicting bioactive conformations was tested. (C) 1997 Elsevier Science Ltd.

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收藏

页码：2729 / 2734

页数：6

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