Microwave Synthesis of a Rare [Ru2L3]4+ Triple Helicate and Its Interaction with DNA

被引：58

作者：

Glasson, Christopher R. K. ^{[1
]}

Meehan, George V. ^{[1
]}

Clegg, Jack K. ^{[2
]}

Lindoy, Leonard F. ^{[2
]}

Smith, Jayden A. ^{[1
]}

Keene, F. Richard ^{[1
]}

Motti, Cherie ^{[3
]}

机构：

[1] James Cook Univ, Sch Pharm & Mol Sci, Townsville, Qld 4811, Australia

[2] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

[3] Australian Inst Marine Sci, Townsville, Qld 4810, Australia

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 34期

基金：

澳大利亚研究理事会;

关键词：

DNA; helicates; metallosupramolecular chemistry; microwave synthesis; ruthenium;

D O I：

10.1002/chem.200801790

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microwave synthesis of a rare [Ru2L3]4+ triple helicate and its interaction with DNA has been demonstrated. Solution of RuCl3 and suspension of L in dry degassed ethylene glycol was used for the study by using microwave energy at a temperature of 225°C. Chromatographic analysis was used to separate the P and M helicates of the racemic mixture of [Ru2L3]4+. A equilibrium dialysis was carried out during the study to investigate the interaction of the racemic mixture of helicate with natural DNA by using calf thymus DNA. Circular dichrosim (CD) determination found the absolute configurations of the P and M helicates. It was observed during the study that the dinuclear helicate can be separated into its P- and M-enantiomers by using DNA-based affinity chromatography.

引用

页码：10535 / 10538

页数：4

共 35 条

[1] Let's twist again - Double-stranded, triple-stranded, and circular helicates [J].

Albrecht, M .

CHEMICAL REVIEWS, 2001, 101 (11) :3457-3497

[2] The unexpected preference for the fac-isomer with the tris(5-ester-substituted-2,2′-bipyridine) complexes of ruthenium(II) [J].

Armstrong, EAP ;

Brown, RT ;

Sekwale, MS ;

Fletcher, NC ;

Gong, XQ ;

Hu, P .

INORGANIC CHEMISTRY, 2004, 43 (05) :1714-1722

[3]

Balzani V, 2007, TOP CURR CHEM, V280, P1, DOI 10.1007/978-3-540-73347-8

[4] Ru(II)-bipyridine complexes in supramolecular systems, devices and machines [J].

Balzani, Vincenzo ;

Bergamini, Giacomo ;

Marchioni, Filippo ;

Ceroni, Paola .

COORDINATION CHEMISTRY REVIEWS, 2006, 250 (11-12) :1254-1266

[5] Homo- and heterometallic [2 x 2] grid arrays containing RuII, OsII, and FeII subunits and their mononuclear RuII and OsII precursors:: Synthesis, absorption spectra, redox behavior, and luminescence properties [J].

Bassani, DM ;

Lehn, JM ;

Serroni, S ;

Puntoriero, F ;

Campagna, S .

CHEMISTRY-A EUROPEAN JOURNAL, 2003, 9 (23) :5936-5946

[6]

Baum G, 1999, CHEM-EUR J, V5, P1862, DOI 10.1002/(SICI)1521-3765(19990604)5:6<1862::AID-CHEM1862>3.3.CO

[7]

2-7

[8] Transition-metal-complexed molecular machine prototypes [J].

Bonnet, Sylvestre ;

Collin, Jean-Paul ;

Koizumi, Masatoshi ;

Mobian, Pierre ;

Sauvage, Jean-Pierre .

ADVANCED MATERIALS, 2006, 18 (10) :1239-1250

[9] Linear and macrocyclic ruthenium(II) complexes containing bis(2,2′:6′,2"-terpyridine) ligands with flexible, naphthalene-centred spacers [J].

Chow, Hoi Shan ;

Constable, Edwin C. ;

Housecroft, Catherine E. ;

Neuburger, Markus ;

Schaffner, Silvia .

POLYHEDRON, 2006, 25 (08) :1831-1843

[10] MLCT excited states and charge delocalization in some ruthenium-ammine-polypyridyl complexes [J].

Endicott, JF ;

Schlegel, HB ;

Uddin, MJ ;

Seniveratne, DS .

COORDINATION CHEMISTRY REVIEWS, 2002, 229 (1-2) :95-106

← 1 2 3 4 →