Curvature Effects in DNA:Au Nanoparticle Conjugates

被引：68

作者：

Cederquist, Kristin B. ^{[1
]}

Keating, Christine D. ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

ACS NANO | 2009年 / 3卷 / 02期

关键词：

MODIFIED GOLD NANOPARTICLES; PROTEIN ADSORPTION; NUCLEIC-ACIDS; CORE SIZE; SURFACES; SILICA; MONOLAYER; PROBES; HYBRIDIZATION; REACTIVITY;

D O I：

10.1021/nn9000726

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA-coated Au nartoparticles have myriad applications as versatile building blocks in nanomaterials assembly, powerful amplification tags for bioanalysis and promising new approaches to medical therapeutics. Characterization, control, and a thorough understanding of the DNA surface interface are essential in the development of these conjugates. A new paper in this issue explores the impact of nanosphere diameter on DNA adsorption and demonstrates that particle curvature plays an important role in controlling the DNA surface density. The study proposes a model that can be used to predict DNA packing on nonspherical particles and validates it using Au nanorods. This work paves the way for improved understanding of the DNA:Au interface in these versatile bioconjugates.

引用

页码：256 / 260

页数：5

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