Elastic sealants for surgical applications

被引：186

作者：

Annabi, Nasim ^{[1
,2
,3
,4
]}

Yue, Kan ^{[2
,3
]}

Tamayol, Ali ^{[2
,3
]}

Khademhosseini, Ali ^{[2
,3
,4
,5
,6
]}

机构：

[1] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Biomat Innovat Res Ctr,Dept Med, Boston, MA 02115 USA

[3] MIT, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[4] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[5] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA

[6] King Abdulaziz Univ, Dept Phys, Jeddah 21569, Saudi Arabia

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2015年 / 95卷

基金：

美国国家科学基金会; 英国医学研究理事会; 美国国家卫生研究院;

关键词：

Surgical sealants; Elasticity; Adhesion; Hydrogel; Surgical applications; Tissue adhesives; BIOMIMETIC TISSUE ADHESIVE; PROLONGED AIR LEAK; FIBRIN SEALANT; CHONDROITIN SULFATE; PHOTOCROSSLINKABLE CHITOSAN; SYNTHETIC SEALANT; CROSS-LINKING; PULMONARY RESECTION; CLINICAL-TRIAL; MUSSEL;

D O I：

10.1016/j.ejpb.2015.05.022

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Sealants have emerged as promising candidates for replacing sutures and staples to prevent air and liquid leakages during and after the surgeries. Their physical properties and adhesion strength to seal the wound area without limiting the tissue movement and function are key factors in their successful implementation in clinical practice. In this contribution, the advances in the development of elastic sealants formed from synthetic and natural materials are critically reviewed and their shortcomings are pointed out. In addition, we highlight the applications in which elasticity of the sealant is critical and outline the limitations of the currently available sealants. This review will provide insights for the development of novel bioadhesives with advanced functionality for surgical applications. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：27 / 39

页数：13

共 115 条

[1]

BIOPHYSICAL PROPERTIES OF THE GELATIN-RESORCINOL-FORMALDEHYDE GLUTARALDEHYDE ADHESIVE [J].