Towards the introduction of the 'Immunoscore' in the classification of malignant tumours

被引：1230

作者：

Galon, Jerome ^{[1
,2
,3
]}

Mlecnik, Bernhard ^{[1
,2
,3
]}

Bindea, Gabriela ^{[1
,2
,3
]}

Angell, Helen K. ^{[1
,2
,3
]}

Berger, Anne ^{[4
]}

Lagorce, Christine ^{[5
]}

Lugli, Alessandro ^{[6
]}

Zlobec, Inti ^{[6
]}

Hartmann, Arndt ^{[7
]}

Bifulco, Carlo ^{[8
]}

Nagtegaal, Iris D. ^{[9
]}

Palmqvist, Richard ^{[10
]}

Masucci, Giuseppe V. ^{[11
]}

Botti, Gerardo ^{[12
]}

Tatangelo, Fabiana ^{[12
]}

Delrio, Paolo ^{[13
]}

Maio, Michele ^{[14
]}

Laghi, Luigi ^{[15
,16
]}

Grizzi, Fabio ^{[15
,16
]}

Asslaber, Martin ^{[17
]}

D'Arrigo, Corrado ^{[18
]}

Vidal-Vanaclocha, Fernando ^{[19
,20
]}

Zavadova, Eva ^{[21
,22
]}

Chouchane, Lotfi ^{[23
]}

Ohashi, Pamela S. ^{[24
,25
]}

Hafezi-Bakhtiari, Sara ^{[26
]}

Wouters, Bradly G. ^{[26
]}

Roehrl, Michael ^{[27
]}

Nguyen, Linh ^{[28
]}

Kawakami, Yutaka ^{[29
]}

Hazama, Shoichi ^{[30
]}

Okuno, Kiyotaka ^{[31
]}

Ogino, Shuji ^{[32
,33
]}

Gibbs, Peter ^{[34
]}

Waring, Paul ^{[35
]}

Sato, Noriyuki ^{[36
]}

Torigoe, Toshihiko

Itoh, Kyogo ^{[37
]}

Patel, Prabhu S. ^{[38
]}

Shukla, Shilin N. ^{[38
]}

Wang, Yili ^{[39
]}

Kopetz, Scott ^{[40
]}

Sinicrope, Frank A. ^{[41
,42
]}

Scripcariu, Viorel ^{[43
]}

Ascierto, Paolo A. ^{[44
]}

Marincola, Francesco M. ^{[45
]}

Fox, Bernard A. ^{[46
,47
]}

Pages, Franck ^{[1
,2
,3
,48
]}

机构：

[1] INSERM, Lab Integrat Canc Immunol, U872, F-75006 Paris, France

[2] Univ Paris 05, Paris, France

[3] Univ Paris 06, Ctr Rech Cordeliers, F-75252 Paris 05, France

[4] Georges Pompidou European Hosp, Dept Digest Surg, Paris, France

[5] Avicenne Hosp, Dept Pathol, Bobigny, France

[6] Univ Bern, Inst Pathol, CH-3012 Bern, Switzerland

[7] Univ Erlangen Nurnberg, Dept Pathol, Erlangen, Germany

[8] Providence Portland Med Ctr, Dept Pathol, Portland, OR USA

[9] Radboud Univ Nijmegen, Med Ctr, Dept Pathol, NL-6525 ED Nijmegen, Netherlands

[10] Umea Univ, Dept Med Biosci, S-90187 Umea, Sweden

[11] Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden

[12] Fdn G Pascale, Ist Nazl Studio & Cura Tumouri, Dept Pathol, Naples, Italy

[13] Fdn G Pascale, Ist Nazl Studio & Cura Tumouri, Dept Colorectal Surg, Naples, Italy

[14] Univ Hosp Siena, Ist Toscano Tumouri, Div Med Oncol & Immunotherapy, Siena, Italy

[15] Humanitas Clin & Res Ctr, Milan, Italy

[16] Humanitas Clin & Res Ctr, Dept Gastroenterol, Milan, Italy

[17] Med Univ Graz, Inst Pathol, Graz, Austria

[18] Dorset Cty Hosp, Dept Histopathol, Dorchester, England

[19] CEU San Pablo Univ, Sch Med, Madrid, Spain

[20] HM Hosp, Madrid Sci Fdn, Inst Appl Mol Med IMMA, Madrid, Spain

[21] Charles Univ Prague, Dept Oncol, Fac Med 1, Prague, Czech Republic

[22] Gen Hosp, Prague, Czech Republic

[23] Weill Cornell Med Coll, Doha, Qatar

[24] Princess Margaret Hosp, Ontario Canc Inst, Univ Hlth Network, Toronto, ON M4X 1K9, Canada

[25] Princess Margaret Hosp, Campbell Family Inst Canc Res, Univ Hlth Network, Toronto, ON M4X 1K9, Canada

[26] Univ Hlth Network, Dept Pathol & Lab Med, Toronto, ON, Canada

[27] Univ Hlth Network, UHN Program BioSpecimen Sci, Toronto, ON, Canada

[28] Univ Hlth Network, Princess Margaret Canc Ctr, Campbell Family Inst Breast Canc Res, Toronto, ON, Canada

[29] Keio Univ, Sch Med, Inst Adv Med Res, Div Cellular Signalling, Tokyo, Japan

[30] Yamaguchi Univ, Grad Sch Med, Dept Digest Surg & Surg Oncol, Yamaguchi, Japan

[31] Kinki Univ, Sch Med, Dept Surg, Osaka 589, Japan

[32] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA

[33] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[34] Royal Melbourne Hosp, Dept Med Oncol, Melbourne, Vic, Australia

[35] Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia

[36] Sapporo Med Univ, Sch Med, Dept Pathol, Sapporo, Hokkaido, Japan

[37] Kurume Univ, Sch Med, Dept Immunol & Immunotherapy, Kurume, Fukuoka, Japan

[38] Gujarat Canc Res Inst, Ahmadabad, Gujarat, India

[39] Xi An Jiao Tong Univ, Ctr Translat Med, Inst Canc Res, Xian 710049, Peoples R China

[40] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[41] Mayo Clin, Rochester, MN 55905 USA

[42] Mayo Coll Med, Rochester, MN 55905 USA

[43] Univ Med & Pharm Gr T Popa, Dept Surg Oncol, Reg Inst Oncol, Dept Surg, Iasi, Romania

[44] Fdn G Pascale, Ist Nazl Studio & Cura Tumouri, Med Oncol & Innovat Therapies Unit, Naples, Italy

[45] Sidra Med & Res Ctr, Res Branch, Doha, Qatar

[46] Providence Portland Med Ctr, Robert W Franz Canc Ctr, Earle A Chiles Res Inst, Lab Mol & Tumour Immunol, Portland, OR USA

[47] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97201 USA

[48] Georges Pompidou European Hosp, Immunol Lab, Paris, France

来源：

JOURNAL OF PATHOLOGY | 2014年 / 232卷 / 02期

关键词：

Immunoscore; colorectal cancer; colon carcinoma; tumour microenvironment; immune response; classification; prognostic markers; predictive markers; T cells; ISLAND METHYLATOR PHENOTYPE; T-CELL SUBSETS; COLORECTAL-CANCER; MICROSATELLITE INSTABILITY; INFILTRATING LYMPHOCYTES; IMMUNE CELLS; PROGNOSTIC-FACTOR; CLINICAL IMPACT; SURVIVAL; POPULATION;

D O I：

10.1002/path.4287

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of colorectal cancer have been proposed, including morphology, cell origin, molecular pathways, mutation status and gene expression-based stratification. These parameters rely on tumour-cell characteristics. Extensive literature has investigated the host immune response against cancer and demonstrated the prognostic impact of the in situ immune cell infiltrate in tumours. A methodology named Immunoscore' has been defined to quantify the in situ immune infiltrate. In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC/UICC TNM classification. An international consortium has been initiated to validate and promote the Immunoscore in routine clinical settings. The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune). (c) 2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

引用

页码：199 / 209

页数：11

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