Will T-cell therapy for cancer ever be a standard of care?

被引:11
作者
Brenner, M. K. [1 ]
机构
[1] Baylor Coll Med, Methodist Hosp, Texas Childrens Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
关键词
cancer; commercialization; T-cell therapy; METASTATIC MELANOMA; COMPLETE RESPONSES; ANTITUMOR-ACTIVITY; SAFETY SWITCH; ADVERSE EVENT; LEUKEMIA; TRANSPLANTATION; IMMUNOTHERAPY; LYMPHOCYTES; PERSISTENCE;
D O I
10.1038/cgt.2012.74
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 [微生物学]; 090105 [作物生产系统与生态工程];
摘要
Cellular therapies for cancer are showing increasing efficacy but their introduction as a 'standard of care' for these disorders is hampered by technical, regulatory and financial concerns. This review identifies some of the major problems and suggests potential solutions.
引用
收藏
页码:818 / 821
页数:4
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共 35 条
[1]
Advances in graft-versus-host disease biology and therapy [J].
Blazar, Bruce R. ;
Murphy, William J. ;
Abedi, Mehrdad .
NATURE REVIEWS IMMUNOLOGY, 2012, 12 (06) :443-458
[2]
Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer [J].
Bollard, Catherine M. ;
Gottschalk, Stephen ;
Leen, Ann M. ;
Weiss, Heidi ;
Straathof, Karin C. ;
Carrum, George ;
Khalil, Mariam ;
Wu, Meng-fen ;
Huls, M. Helen ;
Chang, Chung-Che ;
Gresik, M. Victoria ;
Gee, Adrian P. ;
Brenner, Malcolm K. ;
Rooney, Cliona M. ;
Heslop, Helen E. .
BLOOD, 2007, 110 (08) :2838-2845
[3]
Adapting a transforming growth factor β-related tumor protection strategy to enhance antitumor immunity [J].
Bollard, CM ;
Rössig, C ;
Calonge, MJ ;
Huls, MH ;
Wagner, HJ ;
Massague, J ;
Brenner, MK ;
Heslop, HE ;
Rooney, CM .
BLOOD, 2002, 99 (09) :3179-3187
[4]
Treatment of Chronic Lymphocytic Leukemia With Genetically Targeted Autologous T Cells: Case Report of an Unforeseen Adverse Event in a Phase I Clinical Trial [J].
Brentjens, Renier ;
Yeh, Raymond ;
Bernal, Yvette ;
Riviere, Isabelle ;
Sadelain, Michel .
MOLECULAR THERAPY, 2010, 18 (04) :666-668
[5]
PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine [J].
Cheever, Martin A. ;
Higano, Celestia S. .
CLINICAL CANCER RESEARCH, 2011, 17 (11) :3520-3526
[6]
Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study [J].
Ciceri, Fabio ;
Bonini, Chiara ;
Stanghellini, Maria Teresa Lupo ;
Bondanza, Attilio ;
Traversari, Catia ;
Salomoni, Monica ;
Turchetto, Lucia ;
Colombi, Scialini ;
Bernardi, Massimo ;
Peccatori, Jacopo ;
Pescarollo, Alessandra ;
Servida, Paolo ;
Magnani, Zulma ;
Perna, Serena K. ;
Valtolina, Veronica ;
Crippa, Fulvio ;
Callegaro, Luciano ;
Spoldi, Elena ;
Crocchiolo, Roberto ;
Fleischhauer, Katharina ;
Ponzoni, Maurilio ;
Vago, Luca ;
Rossini, Silvano ;
Santoro, Armando ;
Todisco, Elisabetta ;
Apperley, Jane ;
Olavarria, Eduardo ;
Slavin, Shimon ;
Weissinger, Eva M. ;
Ganser, Arnold ;
Stadler, Michael ;
Yannaki, Evangelia ;
Fassas, Athanasios ;
Anagnostopoulos, Achilles ;
Bregni, Marco ;
Stampino, Corrado Gallo ;
Bruzzi, Paolo ;
Bordignon, Claudio .
LANCET ONCOLOGY, 2009, 10 (05) :489-500
[7]
Cell therapy of stage IV nasopharyngeal carcinoma with autologous Epstein-Barr virus-targeted cytotoxic T lymphocytes [J].
Comoli, P ;
Pedrazzoli, P ;
Maccario, R ;
Basso, S ;
Carminati, O ;
Labirio, M ;
Schiavo, R ;
Secondino, S ;
Frasson, C ;
Perotti, C ;
Moroni, M ;
Locatelli, F ;
Siena, S .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (35) :8942-8949
[8]
Adverse events following infusion of T cells for adoptive immunotherapy: a 10-year experience [J].
Cruz, Conrad Russell ;
Hanley, Patrick J. ;
Liu, Hao ;
Torrano, Vicky ;
Lin, Yu-Feng ;
Arce, James A. ;
Gottschalk, Stephen ;
Savoldo, Barbara ;
Dotti, Gianpietro ;
Louis, Chrystal U. ;
Leen, Ann M. ;
Gee, Adrian P. ;
Rooney, Cliona M. ;
Brenner, Malcolm K. ;
Bollard, Catherine M. ;
Heslop, Helen E. .
CYTOTHERAPY, 2010, 12 (06) :743-749
[9]
Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy [J].
Di Stasi, Antonio ;
Tey, Siok-Keen ;
Dotti, Gianpietro ;
Fujita, Yuriko ;
Kennedy-Nasser, Alana ;
Martinez, Caridad ;
Straathof, Karin ;
Liu, Enli ;
Durett, April G. ;
Grilley, Bambi ;
Liu, Hao ;
Cruz, Conrad R. ;
Savoldo, Barbara ;
Gee, Adrian P. ;
Schindler, John ;
Krance, Robert A. ;
Heslop, Helen E. ;
Spencer, David M. ;
Rooney, Cliona M. ;
Brenner, Malcolm K. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (18) :1673-1683
[10]
Cytotoxic T Lymphocytes Simultaneously Targeting Multiple Tumor-associated Antigens to Treat EBV Negative Lymphoma [J].
Gerdemann, Ulrike ;
Katari, Usha ;
Christin, Anne S. ;
Cruz, Conrad R. ;
Tripic, Tamara ;
Rousseau, Alexandra ;
Gottschalk, Stephen M. ;
Savoldo, Barbara ;
Vera, Juan F. ;
Heslop, Helen E. ;
Brenner, Malcolm K. ;
Bollard, Catherine M. ;
Rooney, Cliona M. ;
Leen, Ann M. .
MOLECULAR THERAPY, 2011, 19 (12) :2258-2268