New heteroaryl-spaced phosphono alpha-amino acids are competitive nmda antagonists with analgesic activity

被引：12

作者：

Swahn, BM

Claesson, A

Pelcman, B

Besidski, Y

Molin, H

Sandberg, MP

Berge, OG

机构：

[1] ASTRA PAIN CONTROL AB,PRECLIN RES,S-15185 SODERTALJE,SWEDEN

[2] ASTRA PAIN CONTROL AB,PRECLIN RES,NOVUM UNIT,S-14157 HUDDINGE,SWEDEN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 14期

关键词：

D O I：

10.1016/0960-894X(96)00288-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and the NMDA receptor binding affinities of alpha-amino-3-(phosphonomethyl)-2-naphthalene-propanoic acid, alpha-amino-3-(phosphonomethyl)-2-benzofuranpropanoic acid, a series of substituted (R)-alpha-amino-3-(phosphonomethyl)-2-quinolinepropanoic acids, (R)-alpha-amino-3-(phosphonomethyl)-1,8-naphthyridine-2-propanoic acid and (R)-alpha-amino-3-(phosphonomethyl)-1,6-naphthyridine-2-propanoic acid are reported. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1635 / 1640

页数：6

共 17 条

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