COMPETITIVE NMDA ANTAGONISTS THAT BASE THEIR ACTIVITY ON A UNIQUE CONFORMATIONAL EFFECT

被引：15

作者：

CLAESSON, A

SWAHN, BM

EDVINSSON, KM

MOLIN, H

SANDBERG, M

机构：

[1] Preclinical Research, Astra Pain Control

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(00)80223-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of two NMDA antagonists, cis-3-(1-oxi-2-phosphonoethyl)-2-piperidine-carboxylic acid and cis-3-(1-hydroxy-2-phosphonoethyl)-2-piperidinecarboxylic acid (1 and 2), is reported. The enantiomers of 1 were also prepared. NMR analysis showed that 1 prefers a 3ax, 2eq chair conformation due to internal hydrogen bonding.

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页码：1247 / 1250

页数：4

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