Grape-derived polyphenolics prevent Aβ oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease

被引：287

作者：

Wang, Jun

Ho, Lap

Zhao, Wei

Ono, Kenjiro ^{[3
,4
]}

Rosensweig, Clark ^{[3
,4
]}

Chen, Linghong

Humala, Nelson

Teplow, David B. ^{[3
,4
]}

Pasinetti, Giulio M. ^{[1
,2
,5
]}

机构：

[1] Mt Sinai Sch Med, Icahn Res Inst, Dept Psychiat, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Brain Res Inst, Dept Neurol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA

[5] James J Peters Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, Bronx, NY 10468 USA

来源：

JOURNAL OF NEUROSCIENCE | 2008年 / 28卷 / 25期

关键词：

Alzheimer's disease; A beta peptide; amyloid beta; cognitive; dementia; Morris water maze; spatial memory;

D O I：

10.1523/JNEUROSCI.0364-08.2008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease ( AD) is a neurodegenerative disorder characterized by progressive impairments in memory and cognition. Extracellular accumulation of soluble high-molecular-weight (HMW) A beta oligomers has been proposed to be largely responsible for AD dementia and memory deficits in the Tg2576 mice, a model of AD. In this study, we found that a naturally derived grape seed polyphenolic extract can significantly inhibit amyloid beta-protein aggregation into high-molecular-weight oligomers in vitro. When orally administered to Tg2576 mice, this polyphenolic preparation significantly attenuates AD-type cognitive deterioration coincidentally with reduced HMW soluble oligomeric A beta in the brain. Our study suggests that grape seed-derived polyphenolics may be useful agents to prevent or treat AD.

引用

页码：6388 / 6392

页数：5

共 33 条

[31] Caloric restriction attenuates β-amyloid neuropathology in a mouse model of Alzheimer's disease [J].