PIG-the pathogen interaction gateway

被引：44

作者：

Driscoll, Tim ^{[1
]}

Dyer, Matthew D. ^{[1
]}

Murali, T. M. ^{[2
]}

Sobral, Bruno W. ^{[1
]}

机构：

[1] Virginia Polytech Inst & State Univ, Virginia Bioinformat Inst, Blacksburg, VA 24061 USA

[2] Virginia Polytech Inst & State Univ, Dept Comp Sci, Blacksburg, VA 24061 USA

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

关键词：

MOLECULAR INTERACTION DATABASE; PROTEIN; RESOURCE; UPDATE;

D O I：

10.1093/nar/gkn799

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Protein-protein interactions (PPIs) play a vital role in initiating infection in a number of pathogens. Identifying which interactions allow a pathogen to infect its host can help us to understand methods of pathogenesis and provide potential targets for therapeutics. Public resources for studying host pathogen systems, in particular PPIs, are scarce. To facilitate the study of host-pathogen PPIs, we have collected and integrated host-pathogen PPI (HP-PPI) data from a number of public resources to create the Pathogen Interaction Gateway (PIG). PIG provides a text based search and a BLAST interface for searching the HP-PPI data. Each entry in PIG includes information such as the functional annotations and the domains present in the interacting proteins. PIG provides links to external databases to allow for easy navigation among the various websites. Additionally, PIG includes a tool for visualizing a single HP-PPI network or two HP-PPI networks. PIG can be accessed at http://pig.vbi.vt.edu.

引用

页码：D647 / D650

页数：4

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