Recent advances in bone tissue engineering scaffolds

被引：2103

作者：

Bose, Susmita ^{[1
]}

Roy, Mangal ^{[1
]}

Bandyopadhyay, Amit ^{[1
]}

机构：

[1] Washington State Univ, Sch Mech & Mat Engn, WM Keck Biomed Mat Res Lab, Pullman, WA 99164 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2012年 / 30卷 / 10期

关键词：

bone scaffolds; biomolecule delivery; osteoinduction; vascularization; biomechanical properties; in vitro and in vivo studies; ENDOTHELIAL GROWTH-FACTOR; CALCIUM-PHOSPHATE SCAFFOLDS; BIOACTIVE GLASS SCAFFOLDS; PROCESSED POROUS TITANIUM; IN-VIVO EVALUATION; SIZE DEFECT MODEL; BIOLOGICAL-PROPERTIES; MORPHOGENETIC PROTEINS; MECHANICAL-PROPERTIES; EXTRACELLULAR-MATRIX;

D O I：

10.1016/j.tibtech.2012.07.005

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Bone disorders are of significant concern due to increase in the median age of our population. Traditionally, bone grafts have been used to restore damaged bone. Synthetic biomaterials are now being used as bone graft substitutes. These biomaterials were initially selected for structural restoration based on their biomechanical properties. Later scaffolds were engineered to be bioactive or bioresorbable to enhance tissue growth. Now scaffolds are designed to induce bone formation and vascularization. These scaffolds are often porous, made of biodegradable materials that harbor different growth factors, drugs, genes, or stem cells. In this review, we highlight recent advances in bone scaffolds and discuss aspects that still need to be improved.

引用

页码：546 / 554

页数：9

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