Binaphthyl-Modiried Quaternary Phosphonium Salts as Chiral Phase-Transfer Catalysts: Asymmetric Amination of β-Keto Esters

被引：189

作者：

He, Rongjun ^{[1
]}

Wang, Xisheng ^{[1
]}

Hashimoto, Takuya ^{[1
]}

Maruoka, Keiji ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Kyoto 6068502, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 49期

关键词：

amination; asymmetric synthesis; phase-transfer catalysis; phosphonium salts; synthetic methods;

D O I：

10.1002/anie.200804140

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A reliable phosphonium-based PTC: For the first time a chiral quaternary tetraalkylphosphonium salt has successfully been used as a phase-transfer catalyst (PTC) for asymmetric amination of β-keto esters, in high yield and with high ee (see scheme). Asymmetric amination of a cyclic five-membered β-keto ester is a valuable method for preparing a key intermediate for asymmetric synthesis of aldose reductase inhibitor AS-3201 (Ranirestat). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9466 / 9468

页数：3

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