Retinoblastoma protein in growth suppression and death protection

被引：79

作者：

Wang, JYJ

机构：

[1] Department of Biology, Univ. California, S. Diego, 9500 G., San Diego

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(97)80107-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Puzzling new information indicates an inadequacy in our understanding of the retinoblastoma protein (RE). RE and the transcription factor E2F appear to be collaborators. RB-E2F interaction is necessary but not sufficient for growth suppression. Unbecoming of a tumor suppressor, RE has an active role in antagonizing the death response. How RE integrates its multiple functions into a tumor suppression program is still an open issue.

引用

收藏

页码：39 / 45

页数：7

相关论文

共 51 条

[11]

DEGREGORI J, 1995, MOL CELL BIOL, V15, P4215

[12] RBF, a novel RE-related gene that regulates E2F activity and interacts with cyclin E in Drosophila [J].

Du, W ;

Vidal, M ;

Xie, JE ;

Dyson, N .

GENES & DEVELOPMENT, 1996, 10 (10) :1206-1218

[13] THE TRANSCRIPTION FACTOR E2F IS REQUIRED FOR S-PHASE DURING DROSOPHILA EMBRYOGENESIS [J].

DURONIO, RJ ;

OFARRELL, PH ;

XIE, JE ;

BROOK, A ;

DYSON, N .

GENES & DEVELOPMENT, 1995, 9 (12) :1445-1455

[14] E2F-1 functions in mice to promote apoptosis and suppress proliferation [J].

Field, SJ ;

Tsai, FY ;

Kuo, F ;

Zubiaga, AM ;

Kaelin, WG ;

Livingston, DM ;

Orkin, SH ;

Greenberg, ME .

CELL, 1996, 85 (04) :549-561

[15] A maize cDNA encoding a member of the retinoblastoma protein family: Involvement in endoreduplication [J].

Grafi, G ;

Burnett, RJ ;

Helentjaris, T ;

Larkins, BA ;

DeCaprio, JA ;

Sellers, WR ;

Kaelin, WG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (17) :8962-8967

[16]

HARVEY M, 1995, CANCER RES, V55, P1146

[17]

Herrera RE, 1996, MOL CELL BIOL, V16, P2402

[18]

HIEBERT SW, 1995, MOL CELL BIOL, V15, P6864

[19] ASSOCIATION OF HUMAN PUR-ALPHA WITH THE RETINOBLASTOMA PROTEIN, RB, REGULATES BINDING TO THE SINGLE-STRANDED-DNA PUR-ALPHA RECOGNITION ELEMENT [J].

JOHNSON, EM ;

CHEN, PL ;

KRACHMAROV, CP ;

BARR, SM ;

KANOVSKY, M ;

MA, ZW ;

LEE, WH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (41) :24352-24360

[20] Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites [J].

Knudsen, ES ;

Wang, JYJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (14) :8313-8320

← 1 2 3 4 5 6 →