Retinoblastoma protein in growth suppression and death protection

被引：79

作者：

Wang, JYJ

机构：

[1] Department of Biology, Univ. California, S. Diego, 9500 G., San Diego

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(97)80107-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Puzzling new information indicates an inadequacy in our understanding of the retinoblastoma protein (RE). RE and the transcription factor E2F appear to be collaborators. RB-E2F interaction is necessary but not sufficient for growth suppression. Unbecoming of a tumor suppressor, RE has an active role in antagonizing the death response. How RE integrates its multiple functions into a tumor suppression program is still an open issue.

引用

页码：39 / 45

页数：7