Frequency specific interactions of MEG resting state activity within and across brain networks as revealed by the multivariate interaction measure

被引:90
作者
Marzetti, L. [1 ,2 ]
Della Penna, S. [1 ,2 ]
Snyder, A. Z. [3 ,4 ]
Pizzella, V. [1 ,2 ]
Nolte, G. [5 ]
de Pasquale, F. [1 ,2 ]
Romani, G. L. [1 ,2 ]
Corbetta, M. [1 ,2 ,3 ,4 ]
机构
[1] G dAnnunzio Univ Chieti Pescara, Dept Neurosci & Imaging, Chieti, Italy
[2] Univ G dAnnunzio, Inst Adv Biomed Technol, I-66013 Chieti, Italy
[3] Washington Univ, Dept Neurol, St Louis, MO USA
[4] Washington Univ, Dept Radiol, St Louis, MO USA
[5] Univ Med Ctr Hamburg Eppendorf, Dept Neurophysiol & Pathophysiol, Hamburg, Germany
基金
美国国家卫生研究院; 英国工程与自然科学研究理事会;
关键词
Imaginary coherence; Magnetoencephalography; Resting state networks; FUNCTIONAL CONNECTIVITY; PHASE-SYNCHRONIZATION; SPATIAL ATTENTION; EEG/MEG DATA; TOP-DOWN; EEG DATA; ALPHA; CORTEX; MAGNETOENCEPHALOGRAPHY; OSCILLATIONS;
D O I
10.1016/j.neuroimage.2013.04.062
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Resting state networks (RSNs) are sets of brain regions exhibiting temporally coherent activity fluctuations in the absence of imposed task structure. RSNs have been extensively studied with fMRI in the infra-slow frequency range (nominally <10(-1) Hz). The topography of fMRI RSNs reflects stationary temporal correlation over minutes. However, neuronal communication occurs on a much faster time scale, at frequencies nominally in the range of 10(0)-10(2) Hz. We examined phase-shifted interactions in the delta (2-3.5 Hz), theta (4-7 Hz), alpha (8-12 Hz) and beta (13-30 Hz) frequency bands of resting-state source space MEG signals. These analyses were conducted between nodes of the dorsal attention network (DAN), one of the most robust RSNs, and between the DAN and other networks. Phase shifted interactions were mapped by the multivariate interaction measure (MIM), a measure of true interaction constructed from the maximization of imaginary coherency in the virtual channels comprised of voxel signals in source space. Non-zero-phase interactions occurred between homologous left and right hemisphere regions of the DAN in the delta and alpha frequency bands. Even stronger non-zero-phase interactions were detected between networks. Visual regions bilaterally showed phase-shifted interactions in the alpha band with regions of the DAN. Bilateral somatomotor regions interacted with DAN nodes in the beta band. These results demonstrate the existence of consistent, frequency specific phase-shifted interactions on a millisecond time scale between cortical regions within RSN as well as across RSNs. (c) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:172 / 183
页数:12
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