Ion channels formed by HIV-1 Vpu: A modelling and simulation study

被引：82

作者：

Grice, AL ^{[1
]}

Kerr, ID ^{[1
]}

Sansom, MSP ^{[1
]}

机构：

[1] UNIV OXFORD,MOL BIOPHYS LAB,OXFORD OX1 3QU,ENGLAND

来源：

FEBS LETTERS | 1997年 / 405卷 / 03期

基金：

英国惠康基金;

关键词：

HIV-1; Vpu; ion channel; molecular dynamics; conductance;

D O I：

10.1016/S0014-5793(97)00198-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vpu is an oligomeric integral membrane protein encoded by HIV-1 which forms ion channels, each subunit of which contains a single transmembrane helix. Models of Vpu channels formed by bundles of N=4, 5 or 6 transmembrane helices have been developed by restrained molecular dynamics and refined by 100 ps simulations with mater molecules within the pore. Pore radius profiles and conductance predictions suggest that the N=5 model corresponds to the predominant channel conductance level of the channel. Potential energy profiles for translation of Na+ or Cl- ions along the Vpu N=5 pore are consistent with the weak cation selectivity of Vpu channels. (C) 1997 Federation of European Biochemical Societies.

引用

页码：299 / 304

页数：6

共 37 条

[1] Simulation of voltage-dependent interactions of alpha-helical peptides with lipid bilayers [J].