The solid phase synthesis of alpha,alpha-disubstituted unnatural amino acids and peptides (di-UPS)

被引：51

作者：

Scott, WL ^{[1
]}

Zhou, CY ^{[1
]}

Fang, ZQ ^{[1
]}

ODonnell, MJ ^{[1
]}

机构：

[1] INDIANA UNIV PURDUE UNIV, DEPT CHEM, INDIANAPOLIS, IN 46202 USA

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 21期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(97)00715-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper reports a new, mild procedure (''di-UPS'') for the solid phase synthesis of racemic alpha,alpha-disubstituted amino acids (1) and epimeric alpha,alpha-disubstituted terminal amino acid residues (2, R-3=H) in a resin bound peptide. The synthetic route is compatible with most protected amino acid side chains and can be used in a continuing solid phase synthesis. DI-UPS should find wide applicability in the design and solid phase synthesis of hybrid amino acids and peptides, and the construction of basis units for combinatorial chemistry. (C) 1997 Elsevier Science Ltd.

引用

页码：3695 / 3698

页数：4

共 43 条

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