Direct catalytic asymmetric cross-aldol reactions in ionic liquid media

被引：143

作者：

Córdova, A ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10611 Stockholm, Sweden

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 20期

关键词：

D O I：

10.1016/j.tetlet.2004.03.080

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective proline-catalyzed direct asymmetric cross-aldol reactions with aldehydes were performed in ionic liquid 1-n-butyl-3-methylimidazolium hexafluorophosphate media, which simplified product isolation and catalyst recycling, affording 3-hydroxy aldehydes in high yield with excellent stereo selectivity. In addition, the enhanced reactivity of the asymmetric cross-aldol reactions in ionic liquid allowed the catalyst loading to be lowered significantly. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3949 / 3952

页数：4

共 31 条

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