Direct catalytic asymmetric cross-aldol reactions in ionic liquid media

被引:143
作者
Córdova, A [1 ]
机构
[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10611 Stockholm, Sweden
关键词
D O I
10.1016/j.tetlet.2004.03.080
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Enantioselective proline-catalyzed direct asymmetric cross-aldol reactions with aldehydes were performed in ionic liquid 1-n-butyl-3-methylimidazolium hexafluorophosphate media, which simplified product isolation and catalyst recycling, affording 3-hydroxy aldehydes in high yield with excellent stereo selectivity. In addition, the enhanced reactivity of the asymmetric cross-aldol reactions in ionic liquid allowed the catalyst loading to be lowered significantly. (C) 2004 Elsevier Ltd. All rights reserved.
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页码:3949 / 3952
页数:4
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