A Personal Journey of Discovery: Developing Technology and Changing Biology

被引：39

作者：

Hood, Lee ^{[1
]}

机构：

[1] Inst Syst Biol, Seattle, WA 98103 USA

来源：

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY | 2008年 / 1卷

关键词：

biological instrumentation and strategies; automated DNA; protein sequencers and synthesizers; cross-disciplinary biology; systems biology; P4; medicine;

D O I：

10.1146/annurev.anchem.1.031207.113113

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This autobiographical article describes my experiences in developing chemically based, biological technologies for deciphering biological information: DNA, RNA, proteins, interactions, and networks. The instruments developed include protein and DNA sequencers and synthesizers, as well as ink-jet technology, for synthesizing DNA chips. Diverse new strategies for doing biology also arose from novel,applications of these instruments. The functioning Of these instruments can be integrated to generate powerful new approaches to cloning and characterizing genes from a small amount of protein sequence or to using gene sequences to synthesize peptide fragments so as to characterize various properties of the proteins. I also discuss the five paradigm changes in which I have participated: the development and integration of biological instrumentation; the human genome project, cross-disciplinary biology; systems biology; and predictive, personalized, preventive, and participatory (P4) medicine. Finally, I discuss the origins, the philosophy, some accomplishments, mid the future trajectories of the Institute for Systems Biology.

引用

收藏

页码：1 / 43

页数：43

相关论文

共 145 条

[21]

Dyson Freeman, 1998, IMAGINED WORLDS

[22] AN APPROACH TO CORRELATE TANDEM MASS-SPECTRAL DATA OF PEPTIDES WITH AMINO-ACID-SEQUENCES IN A PROTEIN DATABASE [J].

ENG, JK ;

MCCORMACK, AL ;

YATES, JR .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1994, 5 (11) :976-989

[23] Base-calling of automated sequencer traces using phred.: I.: Accuracy assessment [J].

Ewing, B ;

Hillier, L ;

Wendl, MC ;

Green, P .

GENOME RESEARCH, 1998, 8 (03) :175-185

[24] General transcription factor specified global gene regulation in archaea [J].

Facciotti, Marc T. ;

Reiss, David J. ;

Pan, Min ;

Kaur, Amardeep ;

Vuthoori, Madhavi ;

Bonneau, Richard ;

Shannon, Paul ;

Srivastava, Alok ;

Donohoe, Samuel M. ;

Hood, Leroy E. ;

Baliga, Nitin S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (11) :4630-4635

[25] Systems biology experimental design - Considerations for building predictive gene regulatory network models for prokaryotic systems [J].

Facciotti, MT ;

Bonneau, R ;

Hood, L ;

Baliga, NS .

CURRENT GENOMICS, 2004, 5 (07) :527-544

[26] Identification of a prostate cancer susceptibility locus on chromosome 7q11-21 in Jewish families [J].

Friedrichsen, DM ;

Stanford, JL ;

Isaacs, SD ;

Janer, M ;

Chang, BL ;

Deutsch, K ;

Gillanders, E ;

Kolb, S ;

Wiley, KE ;

Badzioch, MD ;

Zheng, SL ;

Walsh, PC ;

Jarvik, GP ;

Hood, L ;

Trent, JM ;

Isaacs, WB ;

Ostrander, EA ;

Xu, JF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (07) :1939-1944

[27] A genomic scan of families with prostate cancer identifies multiple regions of interest [J].

Gibbs, M ;

Stanford, JL ;

Jarvik, GP ;

Janer, M ;

Badzioch, M ;

Peters, MA ;

Goode, EL ;

Kolb, S ;

Chakrabarti, L ;

Shook, M ;

Basom, R ;

Ostrander, EA ;

Hood, L .

AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 67 (01) :100-109

[28] Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36 [J].

Gibbs, M ;

Stanford, JL ;

McIndoe, RA ;

Jarvik, GP ;

Kolb, S ;

Goode, EL ;

Chakrabarti, L ;

Schuster, EF ;

Buckley, VA ;

Miller, EL ;

Brandzel, S ;

Li, S ;

Hood, L ;

Ostrander, EA .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 64 (03) :776-787

[29] Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4 [J].

Gilchrist, M ;

Thorsson, V ;

Li, B ;

Rust, AG ;

Korb, M ;

Kennedy, K ;

Hai, T ;

Bolouri, H ;

Aderem, A .

NATURE, 2006, 441 (7090) :173-178

[30] Comparative genomics of the human and mouse T cell receptor loci [J].

Glusman, G ;

Rowen, L ;

Lee, I ;

Boysen, C ;

Roach, JC ;

Smit, AFA ;

Wang, K ;

Koop, BF ;

Hood, L .

IMMUNITY, 2001, 15 (03) :337-349

← 1 2 3 4 5 6 7 8 9 10 →