The emerging limbs and twigs of the East Asian mtDNA tree

被引:320
作者
Kivisild, T
Tolk, HV
Parik, J
Wang, YM
Papiha, SS
Bandelt, HJ
Villems, R
机构
[1] Estonia Bioctr, EE-51010 Tartu, Estonia
[2] Univ Tartu, Dept Evolut Biol, EE-50090 Tartu, Estonia
[3] Newcastle Univ, Dept Human Genet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[4] Univ Hamburg, Dept Math, Hamburg, Germany
关键词
human mitochondrial DNA; population genetics; phylogeography;
D O I
10.1093/oxfordjournals.molbev.a003996
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We determine the phylogenetic backbone of the East Asian mtDNA tree by using published complete mtDNA sequences and assessing both coding and control region variation in 69 Han individuals from southern China. This approach assists in the interpretation of published mtDNA data on East Asians based on either control region sequencing or restriction fragment length polymorphism (RFLP) typing. Our results confirm that the East Asian mtDNA pool is locally region-specific and completely covered by the two superhaplogroups M and N. The phylogenetic partitioning based on complete mtDNA sequences corroborates existing RFLP-based classification of Asian mtDNA types and supports the distinction between northern and southern populations. We describe new haplogroups M7, M8, M9, N9, and R9 and demonstrate by way of example that hierarchically subdividing the major branches of the mtDNA tree aids in recognizing the settlement processes of any particular region in appropriate time scale. This is illustrated by the characteristically southern distribution of haplogroup M7 in East Asia, whereas its daughter-groups, M7a and M7b2, specific for Japanese and Korean populations, testify to a presumably (pre-)Jomon contribution to the modern mtDNA pool of Japan.
引用
收藏
页码:1737 / 1751
页数:15
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