PARsing the Phrase "All in for Axin" - Wnt Pathway Targets in Cancer

被引：37

作者：

Fearon, Eric R. ^{[1
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机构：

[1] Univ Michigan, Div Mol Med & Genet, Dept Internal Med, Sch Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Human Genet, Sch Med, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Pathol, Sch Med, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Ctr Canc, Sch Med, Ann Arbor, MI 48109 USA

来源：

CANCER CELL | 2009年 / 16卷 / 05期

关键词：

BETA-CATENIN; CELLS;

D O I：

10.1016/j.ccr.2009.10.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genetic alternations resulting in constitutive stabilization of beta-catenin and altered transcription of beta-catenin/TCF-regulated genes are found in many cancers. A recent Nature paper offers insights into the role of tankyrase in regulating the Wnt/beta-catenin pathway and suggests that compounds targeting tankyrase's poly-ADP-ribosylation (PARsylation) activity may hold promise for cancer therapy.

引用

页码：366 / 368

页数：3

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