Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus Hemagglutinin

被引：97

作者：

Dreyfus, Cyrille ^{[1
]}

Ekiert, Damian C. ^{[1
]}

Wilson, Ian A. ^{[1
,2
]}

机构：

[1] Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 12期

关键词：

MONOCLONAL-ANTIBODY; PROTECTS MICE; EPITOPE; RECEPTOR; BINDING; DESIGN; H1;

D O I：

10.1128/JVI.02975-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report the structural characterization of the first antibody identified to cross-neutralize multiple subtypes of influenza A viruses. The crystal structure of mouse antibody C179 bound to the pandemic 1957 H2N2 hemagglutinin (HA) reveals that it targets an epitope on the HA stem similar to those targeted by the recently identified human broadly neutralizing antibodies. C179 also inhibits the low-pH conformational change of the HA but uses a different angle of approach and both heavy and light chains.

引用

页码：7149 / 7154

页数：6

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