Highly Conserved Protective Epitopes on Influenza B Viruses

被引：663

作者：

Dreyfus, Cyrille ^{[1
]}

Laursen, Nick S. ^{[1
,2
]}

Kwaks, Ted ^{[3
]}

Zuijdgeest, David ^{[3
]}

Khayat, Reza ^{[1
]}

Ekiert, Damian C. ^{[1
]}

Lee, Jeong Hyun ^{[1
]}

Metlagel, Zoltan ^{[1
]}

Bujny, Miriam V. ^{[3
]}

Jongeneelen, Mandy ^{[3
]}

van der Vlugt, Remko ^{[3
]}

Lamrani, Mohammed ^{[3
]}

Korse, Hans J. W. M. ^{[3
]}

Geelen, Eric ^{[3
]}

Sahin, Ozcan ^{[3
]}

Sieuwerts, Martijn ^{[3
]}

Brakenhoff, Just P. J. ^{[3
]}

Vogels, Ronald ^{[3
]}

Li, Olive T. W. ^{[4
,5
]}

Poon, Leo L. M. ^{[4
,5
]}

Peiris, Malik ^{[4
,5
]}

Koudstaal, Wouter ^{[3
]}

Ward, Andrew B. ^{[1
]}

Wilson, Ian A. ^{[1
,6
]}

Goudsmit, Jaap ^{[3
]}

Friesen, Robert H. E. ^{[3
]}

机构：

[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[2] Aarhus Univ, Dept Mol Biol, DK-8000 Aarhus, Denmark

[3] Janssen Ctr Excellence Immunoprophylaxis, Crucell Vaccine Inst, NL-2301 CA Leiden, Netherlands

[4] Univ Hong Kong, State Key Lab Emerging Infect Dis, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China

[5] Univ Hong Kong, Sch Publ Hlth, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China

[6] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

SCIENCE | 2012年 / 337卷 / 6100期

关键词：

A VIRUSES; ANTIBODY; HEMAGGLUTININ; BROAD; NEUTRALIZATION; RECOGNIZES; LINEAGES; HIV-1; CELLS;

D O I：

10.1126/science.1222908

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a substantial part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody-based treatments and a universal flu vaccine for all influenza A and B viruses.

引用

页码：1343 / 1348

页数：6

共 25 条

[1] The rationale for quadrivalent influenza vaccines [J].

Ambrose, Christopher S. ;

Levin, Myron J. .

HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2012, 8 (01) :81-88

[2]

[Anonymous], FACT SHEET 211 INFL

[3] The influenza virus resource at the national center for biotechnology information [J].

Bao, Yiming ;

Bolotov, Pavel ;

Dernovoy, Dmitry ;

Kiryutin, Boris ;

Zaslavsky, Leonid ;

Tatusova, Tatiana ;

Ostell, Jim ;

Lipman, David .

JOURNAL OF VIROLOGY, 2008, 82 (02) :596-601

[4] A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins [J].

Corti, Davide ;

Voss, Jarrod ;

Gamblin, Steven J. ;

Codoni, Giosiana ;

Macagno, Annalisa ;

Jarrossay, David ;

Vachieri, Sebastien G. ;

Pinna, Debora ;

Minola, Andrea ;

Vanzetta, Fabrizia ;

Silacci, Chiara ;

Fernandez-Rodriguez, Blanca M. ;

Agatic, Gloria ;

Bianchi, Siro ;

Giacchetto-Sasselli, Isabella ;

Calder, Lesley ;

Sallusto, Federica ;

Collins, Patrick ;

Haire, Lesley F. ;

Temperton, Nigel ;

Langedijk, Johannes P. M. ;

Skehel, John J. ;

Lanzavecchia, Antonio .

SCIENCE, 2011, 333 (6044) :850-856

[5] A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses [J].

Ekiert, Damian C. ;

Friesen, Robert H. E. ;

Bhabha, Gira ;

Kwaks, Ted ;

Jongeneelen, Mandy ;

Yu, Wenli ;

Ophorst, Carla ;

Cox, Freek ;

Korse, Hans J. W. M. ;

Brandenburg, Boerries ;

Vogels, Ronald ;

Brakenhoff, Just P. J. ;

Kompier, Ronald ;

Koldijk, Martin H. ;

Cornelissen, Lisette A. H. M. ;

Poon, Leo L. M. ;

Peiris, Malik ;

Koudstaal, Wouter ;

Wilson, Ian A. ;

Goudsmit, Jaap .

SCIENCE, 2011, 333 (6044) :843-850

[6] Antibody Recognition of a Highly Conserved Influenza Virus Epitope [J].

Ekiert, Damian C. ;

Bhabha, Gira ;

Elsliger, Marc-Andre ;

Friesen, Robert H. E. ;

Jongeneelen, Mandy ;

Throsby, Mark ;

Goudsmit, Jaap ;

Wilson, Ian A. .

SCIENCE, 2009, 324 (5924) :246-251

[7] Influenza virus neuraminidase inhibitors [J].

Gubareva, LV ;

Kaiser, L ;

Hayden, FG .

LANCET, 2000, 355 (9206) :827-835

[8] X-ray structure of the hemagglutinin of a potential H3 avian progenitor of the 1968 Hong Kong pandemic influenza virus [J].

Ha, Y ;

Stevens, DJ ;

Skehel, JJ ;

Wiley, DC .

VIROLOGY, 2003, 309 (02) :209-218

[9] A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin [J].

Krause, Jens C. ;

Tsibane, Tshidi ;

Tumpey, Terrence M. ;

Huffman, Chelsey J. ;

Basler, Christopher F. ;

Crowe, James E., Jr. .

JOURNAL OF VIROLOGY, 2011, 85 (20) :10905-10908

[10]

Lowen Anice C., 2007, Infectious Disorders - Drug Targets, V7, P318

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