MicroRNA biogenesis: there's more than one way to skin a cat

被引：73

作者：

Faller, Michael ^{[1
]}

Guo, Feng ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biol Chem, Inst Mol Biol, Los Angeles, CA 90095 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2008年 / 1779卷 / 11期

关键词：

microRNA; Ribonuclease; RNA-binding protein; RNA polymerase; Spliceosome; Adenosine deaminase for RNA;

D O I：

10.1016/j.bbagrm.2008.08.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

microRNAs (miRNAs) are extensively involved in developmental programming. Some miRNAs are highly conserved, while others are lineage specific. All miRNAs maturate through a series of processing steps. Here review recent progresses in the studies of early steps in miRNA biogenesis, focusing on animal systems. miRNA maturation pathways are surprisingly diverse, involving transcription by RNA polymerase II or III, cleavage by the Drosha nuclease or the spliceosome, and sometimes modifications by the adenosine deaminase ADAR. The relationship between the diversity in miRNA biogenesis and the apparently rapid evolution of miRNA genes and functions is discussed. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：663 / 667

页数：5

共 97 条

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