A reversed phase high performance liquid chromatography method for the analysis of boswellic acids in Boswellia serrata

被引:35
作者
Ganzera, M
Khan, IA [1 ]
机构
[1] Univ Mississippi, NCNPR, Pharmaceut Sci Res Inst, University, MS 38677 USA
[2] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA
关键词
D O I
10.1055/s-2001-18346
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
An HPLC method for the separation of boswellic acids, the active constituents In Boswellia serrata resin has been developed. The first accurate determination of 6 individual acids was possible in the resin as well as in multi-component preparations. By using an acidic mobile phase, raised temperature and a 4 mum Synergi MAX-RP 80 Angstrom column the acids could be detected at levels as low as 0.9 mug/ml. The study of market products revealed significant variations in the content of these pharmacologically active compounds in commercial samples.
引用
收藏
页码:778 / 780
页数:3
相关论文
共 9 条
[1]  
GUPA V, 1985, INDIAN DRUGS, V22, P222
[2]  
Hahn-Deinstrop E, 1998, JPC-J PLANAR CHROMAT, V11, P404
[3]  
HANSEL R, 1999, PHARMAKOGNOSIE PHYTO, P521
[4]  
KAPOOR LD, 1990, CRC HDB AYURVEDIC, P83
[5]   Effects of Boswellic acid of Boswellia serrata and other triterpenic acids on the complement system [J].
Knaus, U ;
Wagner, H .
PHYTOMEDICINE, 1996, 3 (01) :77-80
[6]  
Leung A.Y., 1996, ENCY COMMON NATURAL, P389
[7]  
NADKARNI KM, 1954, INDIAN MED, P211
[8]   Concentration-dependent potentiating and inhibitory effects of Boswellia extracts on 5-lipoxygenase product formation in stimulated PMNL [J].
Safayhi, H ;
Boden, SE ;
Schweizer, S ;
Ammon, HPT .
PLANTA MEDICA, 2000, 66 (02) :110-113
[9]   Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture [J].
Shao, Y ;
Ho, CT ;
Chin, CK ;
Badmaev, V ;
Ma, W ;
Huang, MT .
PLANTA MEDICA, 1998, 64 (04) :328-331