Synthesis and antiviral activity of modified 1,2,6-thiadiazine dioxide acyclonucleosides

被引：8

作者：

Esteban, AI

DeClercq, E

Martinez, A

机构：

[1] CSIC, INST QUIM MED, E-28006 MADRID, SPAIN

[2] CATHOLIC UNIV LEUVEN, REGA INST MED RES, B-3000 LOUVAIN, BELGIUM

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1997年 / 16卷 / 03期

关键词：

D O I：

10.1080/07328319708001347

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Modified 1,2,6-thiadiazine dioxide acyclonucleosides were synthesized using the silylation method. All the compounds were tested as antiviral agents in a wide variety of assay systems. With two compounds, some activity (20, 35 and 14 mu g/mL, respectively) was noted against herpes simplex virus, human cytomegalovirus and varicella-zoster virus.

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页码：265 / 276

页数：12

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