Multiple solid phase synthesis of (RS)-1-aminophosphinic acids

被引：31

作者：

Boyd, EA

Chan, WC

Loh, VM

机构：

[1] Dept. of Pharmaceutical Sciences, University of Nottingham, Nottingham, NG7 2RD, University Park

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 10期

关键词：

D O I：

10.1016/0040-4039(96)00082-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel resin bound (RS)-1-aminophosphinic acids, prepared by the facile addition of bis(trimethylsilyl)phosphonite to 9-aryl or alkylimino-xanthen-3-yloxymethyl polystyrene, on acidolysis afforded (RS)-1-aminophosphinic acids in high yields and purities.

引用

页码：1647 / 1650

页数：4

共 15 条

[1] SYNTHESIS OF GAMMA-KETO-SUBSTITUTED PHOSPHINIC ACIDS FROM BIS(TRIMETHYLSILYL)PHOSPHONITE AND ALPHA,BETA-UNSATURATED KETONES
BOYD, EA
REGAN, AC
JAMES, K
[J]. TETRAHEDRON LETTERS, 1992, 33 (06) : 813 - 816
[2] SYNTHESIS OF ALKYL PHOSPHINIC ACIDS FROM SILYL PHOSPHONITES AND ALKYL-HALIDES
BOYD, EA
REGAN, AC
JAMES, K
[J]. TETRAHEDRON LETTERS, 1994, 35 (24) : 4223 - 4226
[3] SOLID-PHASE SYNTHESIS OF PHOSPHINIC PEPTIDES
CAMPAGNE, JM
COSTE, J
GUILLOU, L
HEITZ, A
JOUIN, P
[J]. TETRAHEDRON LETTERS, 1993, 34 (26) : 4181 - 4184
[4] FACILE SYNTHESIS OF PROTECTED C-TERMINAL PEPTIDE SEGMENTS BY FMOC/BU(T) SOLID-PHASE PROCEDURES ON N-FMOC-9-AMINO-XANTHEN-3-YLOXYMETHYL POLYSTYRENE RESIN
CHAN, WC
WHITE, PD
BEYTHIEN, J
STEINAUER, R
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (05) : 589 - 592
[5] REDUCTIVE ALKYLATION OF 9-AMINO-XANTHEN-3-YLOXYMETHYLPOLY(STYRENE) - A NOVEL PROCEDURE FOR THE SYNTHESIS OF PEPTIDYL N-ALKYL AMIDES BY FMOC/BU(T) CHEMISTRY
CHAN, WC
MELLOR, SL
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (14) : 1475 - 1477
[6] APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .2. COMBINATORIAL ORGANIC-SYNTHESIS, LIBRARY SCREENING STRATEGIES, AND FUTURE-DIRECTIONS
GORDON, EM
BARRETT, RW
DOWER, WJ
FODOR, SPA
GALLOP, MA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (10) : 1385 - 1401
[7] GORDON EM, 1994, J MED CHEM, V37, P1233
[8] INHIBITION OF STROMELYSIN-1 (MMP-3) BY PEPTIDYL PHOSPHINIC ACIDS
GOULET, JL
KINNEARY, JF
DURETTE, PL
STEIN, RL
HARRISON, RK
IZQUIERDOMARTIN, M
KUO, DW
LIN, TY
HAGMANN, WK
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (10) : 1221 - 1224
[9] A PHOSPHINIC ACID DIPEPTIDE ANALOG TO STABILIZE PEPTIDE DRUGS DURING THEIR INTRANASAL ABSORPTION
HUSSAIN, MA
LIM, MSL
RAGHAVAN, KS
ROGERS, NJ
HIDALGO, R
KETTNER, CA
[J]. PHARMACEUTICAL RESEARCH, 1992, 9 (05) : 626 - 628
[10] JIAO XY, 1994, SYNTHESIS-STUTTGART, P23

← 1 2 →