Treatment of local anesthetic-induced cardiotoxicity using drug scavenging nanoparticles

被引：25

作者：

Morey, TE

Varshney, M

Flint, JA

Rajasekaran, S

Shah, DO

Dennis, DM

机构：

[1] Univ Florida, Dept Anesthesiol, Particle Engn Res Ctr, Gainesville, FL 32610 USA

[2] Univ Florida, Dept Chem Engn, Particle Engn Res Ctr, Gainesville, FL 32610 USA

来源：

NANO LETTERS | 2004年 / 4卷 / 04期

关键词：

D O I：

10.1021/nl049880w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Because of its ability to create structures of nanoscale dimension with large aggregate particle surface area-to-volume ratios, nanotechnology offers new opportunities to treat drug poisonings. Emulsion-based nanoparticles (diameter: 118.4 nm) extracted bupivacaine from the aqueous phase in a physiological salt solution and attenuated the drug's cardiotoxicity in guinea pig heart to a greater extent than did a macroemulsion (432.0 nm). Additionally, nanoparticles sequestered bupivacaine from the aqueous phase of human blood and merit further investigation in animal models of intoxication.

引用

收藏

页码：757 / 759

页数：3

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