Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

被引：3486

作者：

Hanahan, Douglas ^{[1
]}

Coussens, Lisa M. ^{[2
,3
]}

机构：

[1] Swiss Fed Inst Technol Lausanne EPFL, Sch Life Sci, Swiss Inst Expt Canc Res ISREC, CH-1015 Lausanne, Switzerland

[2] Oregon Hlth & Sci Univ, Dept Cell & Dev Biol, Portland, OR 97239 USA

[3] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97239 USA

来源：

CANCER CELL | 2012年 / 21卷 / 03期

关键词：

ENDOTHELIAL GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; INFILTRATING MYELOID CELLS; BREAST-CANCER; ANTIANGIOGENIC THERAPY; MAST-CELLS; ANGIOGENIC SWITCH; CLINICAL-APPLICATIONS; EXTRACELLULAR-MATRIX; MOLECULAR-MECHANISMS;

D O I：

10.1016/j.ccr.2012.02.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mutationally corrupted cancer (stem) cells are the driving force of tumor development and progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly normal tissue and bone marrow-derived (stromal) cells are recruited to constitute tumorigenic microenvironments. Most of the hallmarks of cancer are enabled and sustained to varying degrees through contributions from repertoires of stromal cell types and distinctive subcell types. Their contributory functions to hallmark capabilities are increasingly well understood, as are the reciprocal communications with neoplastic cancer cells that mediate their recruitment, activation, programming, and persistence. This enhanced understanding presents interesting new targets for anticancer therapy.

引用

页码：309 / 322

页数：14

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