Antiviral Chinese medicinal herbs against respiratory syncytial virus

被引：290

作者：

Ma, SC

Du, J

But, PPH ^{[1
]}

Deng, XL

Zhang, YW

Ooi, VEC

Xu, HX

Lee, SHS

Lee, SF

机构：

[1] Chinese Univ Hong Kong, Dept Biol, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China

[3] Dalhousie Univ, Dept Microbiol & Immunol, Halifax, NS, Canada

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2002年 / 79卷 / 02期

关键词：

Chinese medicine; cytotoxicity; antiviral; respiratory syncytial virus; Sophora flavescens; Scutellaria baicalensis;

D O I：

10.1016/S0378-8741(01)00389-0

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Forty-four medicinal herbs were tested for antiviral activities against respiratory syncytial virus (RSV) by means of the cytopathologic effect (CPE) assay. Twenty-seven of the 44 medicinal herbs showed potent or moderate antiviral activities against RSV with 50% inhibition concentration (IC50) ranging from 6.3 to 52.1 mug/ml, and with selectivity index (SI) ranging from 2.0 to 32.1. Further purification of the active extracts from Sophora flavescens Ait. and Scutellaria baicalensis Georgi led to the identification of anagyrine (2), oxymatrine (7), sophoranol (10), wogonin (12), and oroxylin A (13) as the potent anti-RSV components. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

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页码：205 / 211

页数：7

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