A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273

被引：40

作者：

Liu, JH ^{[1
]}

Chen, YG ^{[1
]}

Yu, BY ^{[1
]}

Chen, YJ ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Complex Prescript TCM, Nanjing 210038, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 07期

基金：

中国国家自然科学基金;

关键词：

biotransformation; Streptomyces griseus ATCC 13273; artemisinin; regioselectivity; artemisitone-9;

D O I：

10.1016/j.bmcl.2005.12.076

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A novel ketone derivative of artemisinin, artemisitone-9, was produced by the biotransformation of cultured Streptomyces griseus ATCC 13273. The structure of the ketone product Was fully elucidated by various spectroscopic techniques, and the mechanism of generating Such novel metabolite is also discussed. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1909 / 1912

页数：4

共 17 条

[1]

Microbial transformation of artemether [J].

Abourashed, EA ;

Hufford, CD .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (03) :251-253

[2]

MICROBIAL TRANSFORMATIONS OF ANTITUMOR COMPOUNDS .1. CONVERSION OF ACRONYCINE TO 9-HYDROXYACRONYCINE BY CUNNINGHAMELLA-ECHINULATA [J].

BETTS, RE ;

WALTERS, DE ;

ROSAZZA, JP .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (06) :599-602

[3]

DEFINITIVE H-1-NMR AND C-13-NMR ASSIGNMENTS OF ARTEMISININ (QINGHAOSU) [J].

BLASKO, G ;

CORDELL, GA ;

LANKIN, DC .

JOURNAL OF NATURAL PRODUCTS, 1988, 51 (06) :1273-1276

[4]

IDENTIFICATION OF THE INVIVO METABOLITES OF THE ANTIMALARIAL ARTEETHER BY THERMOSPRAY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY [J].

CHI, HT ;

RAMU, K ;

BAKER, JK ;

HUFFORD, CD ;

LEE, IS ;

ZENG, YL ;

MCCHESNEY, JD .

BIOLOGICAL MASS SPECTROMETRY, 1991, 20 (10) :609-628

[5]

QUANTITATIVE ASSESSMENT OF ANTI-MALARIAL ACTIVITY INVITRO BY A SEMIAUTOMATED MICRODILUTION TECHNIQUE [J].

DESJARDINS, RE ;

CANFIELD, CJ ;

HAYNES, JD ;

CHULAY, JD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 16 (06) :710-718

[6]

Hydroxylations and methylations of quercetin, fisetin, and catechin by Streptomyces griseus [J].

Hosny, M ;

Dhar, K ;

Rosazza, JPN .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (04) :462-465

[7]

1-ALPHA-HYDROXYARTEETHER, A NEW MICROBIAL TRANSFORMATION PRODUCT [J].

HUFFORD, CD ;

KHALIFA, SI ;

ORABI, KY ;

WIGGERS, FT ;

KUMAR, R ;

ROGERS, RD ;

CAMPANA, CF .

JOURNAL OF NATURAL PRODUCTS-LLOYDIA, 1995, 58 (05) :751-755

[8]

STRUCTURE ELUCIDATION AND THERMOSPRAY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY MASS-SPECTROSCOPY (HPLC/MS) OF THE MICROBIAL AND MAMMALIAN METABOLITES OF THE ANTIMALARIAL ARTEETHER [J].

HUFFORD, CD ;

LEE, IS ;

ELSOHLY, HN ;

CHI, HT ;

BAKER, JK .

PHARMACEUTICAL RESEARCH, 1990, 7 (09) :923-927

[9]

MICROBIAL AND MAMMALIAN METABOLISM STUDIES OF THE SEMISYNTHETIC ANTIMALARIAL, ANHYDRODIHYDROARTEMISININ [J].

KHALIFA, SI ;

BAKER, JK ;

ROGERS, RD ;

ELFERALY, FS ;

HUFFORD, CD .

PHARMACEUTICAL RESEARCH, 1994, 11 (07) :990-994

[10]

QINGHAOSU (ARTEMISININ) - AN ANTIMALARIAL DRUG FROM CHINA [J].

KLAYMAN, DL .

SCIENCE, 1985, 228 (4703) :1049-1055

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