Synthesis and anticonvulsant activity of 3-aryl-5H-2,3-benzodiazepine AMPA antagonists

被引：27

作者：

Anderson, BA ^{[1
]}

Harn, NK

Hansen, MM

Harkness, AR

Lodge, D

Leander, JD

机构：

[1] Lilly Res Labs, Chem Proc Res & Dev Div, Indianapolis, IN 46285 USA

[2] Lilly Corp Ctr, Neurosci Res Div, Indianapolis, IN 46285 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(99)00315-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of 3-aryl-5H-2,3-benzodiazepines. with N-3 aromatic substituents has been synthesized. Good in vivo anticonvulsant activity of the new compounds has been demonstrated employing the maximal electroshock seizure test in mice. Evaluation of a subset of the compounds in the cortical wedge assay confirmed the new structures to be AMPA antagonists. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1953 / 1956

页数：4

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