Rapid Enantiomeric Excess and Concentration Determination Using Simple Racemic Metal Complexes

被引：36

作者：

Nieto, Sonia ^{[1
]}

Lynch, Vincent M. ^{[1
]}

Anslyn, Eric V. ^{[1
]}

Kim, Hyunwoo ^{[2
]}

Chin, Jik ^{[2
]}

机构：

[1] Univ Texas Austin, Dept Chem & Biochem, Austin, TX 78712 USA

[2] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 22期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1021/ol802085j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Racemic-metal complexes were used to determine identity, enantiomeric excess, and concentration of chiral diamines using metal-to-ligand charge transfer bands in circular dichroism spectroscopy. It takes under just 2 min per sample to determine [G](t) and %R with tolerable errors (19% and 4%, respectively). The simplicity of the achiral receptors employed confers to this technique great potential for high-throughput screening.

引用

页码：5167 / 5170

页数：4

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