Asymmetric aza-Michael reactions of α,β-unsaturated ketones with bifunctional organic catalysts

被引：106

作者：

Lu, Xiaojie ^{[1
]}

Deng, Li ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 40期

关键词：

alkaloids; amines; asymmetric catalysis; enones; Michael addition;

D O I：

10.1002/anie.200802785

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synergy makes it possible: Bifunctional cinchona alkaloids are found to promote the first highly enantioselective organocatalytic aza-Michael reactions with α,β-unsaturated ketones. In addition to utilizing practical catalysts, readily accessible substrates, and commercially available reagents, this reaction affords a synthetically valuable scope that is complimentary to existing methods catalyzed by chiral metal complexes. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7710 / 7713

页数：4

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