Engineering secondary metabolite production in plants

被引：221

作者：

Verpoorte, R ^{[1
]}

Memelink, J

机构：

[1] Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Pharmacognosy, Leiden, Netherlands

[2] Leiden Univ, Inst Mol Plant Sci, Leiden, Netherlands

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2002年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0958-1669(02)00308-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent achievements have been made in the metabolic engineering of plant secondary metabolism. Various pathways have been altered using genes encoding biosynthetic enzymes or genes encoding regulatory proteins. In addition, antisense genes have been used to block competitive pathways, thereby increasing the flux towards the desired secondary metabolites.

引用

页码：181 / 187

页数：7

共 58 条

[1] The strawberry FaMYB1 transcription factor suppresses anthocyanin and flavonol accumulation in transgenic tobacco [J].

Aharoni, A ;

De Vos, CHR ;

Wein, M ;

Sun, ZK ;

Greco, R ;

Kroon, A ;

Mol, JNM ;

O'Connell, AP .

PLANT JOURNAL, 2001, 28 (03) :319-332

[2] Metabolic engineering of p-hydroxybenzylglucosinolate in Arabidopsis by expression of the cyanogenic CYP79A1 from Sorghum bicolor [J].

Bak, S ;

Olsen, CE ;

Petersen, BL ;

Moller, BL ;

Halkier, BA .

PLANT JOURNAL, 1999, 20 (06) :663-671

[3] Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis [J].

Borevitz, JO ;

Xia, YJ ;

Blount, J ;

Dixon, RA ;

Lamb, C .

PLANT CELL, 2000, 12 (12) :2383-2393

[4] Progress in plant metabolic engineering [J].

Broun, P ;

Somerville, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (16) :8925-8927

[5] Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus [J].

Canel, C ;

Lopes-Cardoso, MI ;

Whitmer, S ;

van der Fits, L ;

Pasquali, G ;

van der Heijden, R ;

Hoge, JHC ;

Verpoorte, R .

PLANTA, 1998, 205 (03) :414-419

[6] Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation [J].

Chen, DH ;

Ye, HC ;

Li, GF .

PLANT SCIENCE, 2000, 155 (02) :179-185

[7] Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis [J].

Collu, G ;

Unver, N ;

Peltenburg-Looman, AMG ;

van der Heijden, R ;

Verpoorte, R ;

Memelink, J .

FEBS LETTERS, 2001, 508 (02) :215-220

[8]

Davies K.M., 2000, METABOLIC ENG PLANT, P127

[9] Plant metabolic engineering [J].

DellaPenna, D .

PLANT PHYSIOLOGY, 2001, 125 (01) :160-163

[10] Natural products and plant disease resistance [J].

Dixon, RA .

NATURE, 2001, 411 (6839) :843-847

← 1 2 3 4 5 6 →